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. 1978 Feb;13(2):344–346. doi: 10.1128/aac.13.2.344

Treatment of a Murine Cytomegalovirus Infection with Exogenous Interferon, Polyinosinic-Polycytidylic Acid, and Polyinosinic-Polycytidylic Acid–Poly-l-Lysine Complex†

Earl R Kern 1,2, Gregg A Olsen 2, James C Overall Jr 1,2, Lowell A Glasgow 1,2
PMCID: PMC352239  PMID: 206203

Abstract

Treatment of a cytomegalovirus infection of mice with exogenous murine interferon did not alter final mortality or mean day of death. Pretreatment with two interferon inducers significantly reduced mortality, but treatment initiated after infection was not effective.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arvin A. M., Yeager A. S., Merigan T. C. Effect of leukocyte interferon on urinary excretion of cytomegalovirus by infants. J Infect Dis. 1976 Jun;133 (Suppl):A205–A210. doi: 10.1093/infdis/133.supplement_2.a205. [DOI] [PubMed] [Google Scholar]
  2. Emödi G., O'Reilly R., Müller A., Everson L. K., Binswanger U., Just M. Effect of human exogenous leukocyte interferon in cytomegalovirus infections. J Infect Dis. 1976 Jun;133 (Suppl):A199–A204. doi: 10.1093/infdis/133.supplement_2.a199. [DOI] [PubMed] [Google Scholar]
  3. Glasgow L. A., Hanshaw J. B., Merigan T. C., Petralli J. K. Interferon and cytomegalovirus in vivo and in vitro. Proc Soc Exp Biol Med. 1967 Jul;125(3):843–849. doi: 10.3181/00379727-125-32220. [DOI] [PubMed] [Google Scholar]
  4. Gresser I., Tovey M. G., Bourali-Maury C. Efficacy of exogenous interferon treatment initiated after onset of multiplication of vesicular stomatitis virus in the brains of mice. J Gen Virol. 1975 Jun;27(3):395–398. doi: 10.1099/0022-1317-27-3-395. [DOI] [PubMed] [Google Scholar]
  5. HO M., ENDERS J. F. Further studies on an inhibitor of viral activity appearing in infected cell cultures and its role in chronic viral infections. Virology. 1959 Nov;9:446–477. doi: 10.1016/0042-6822(59)90135-7. [DOI] [PubMed] [Google Scholar]
  6. Kelsey D. K., Kern E. R., Overall J. C., Jr, Glasgow L. A. Effect of cytosine arabinoside and 5-iodo-2'-deoxyuridine on a cytomegalovirus infection in newborn mice. Antimicrob Agents Chemother. 1976 Mar;9(3):458–464. doi: 10.1128/aac.9.3.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kern E. R., Glasgow L. A. Effect of interferon on systemic herpesvirus infections. Tex Rep Biol Med. 1977;35:472–477. [PubMed] [Google Scholar]
  8. Kern E. R., Overall J. C., Jr, Glasgow L. A. Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine. J Infect Dis. 1973 Sep;128(3):290–299. doi: 10.1093/infdis/128.3.290. [DOI] [PubMed] [Google Scholar]
  9. Kern E. R., Overall J. C., Jr, Glasgow L. A. Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid. Antimicrob Agents Chemother. 1975 Jun;7(6):793–800. doi: 10.1128/aac.7.6.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Oh J. O. Sensitivity of Types 1 and 2 Herpesvirus hominis to an Interferon Inducer, Poly I:C. Infect Immun. 1971 Jun;3(6):847–848. doi: 10.1128/iai.3.6.847-848.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Oie H. K., Easton J. M., Ablashi D. V., Baron S. Murine cytomegalovirus: induction of and sensitivity to interferon in vitro. Infect Immun. 1975 Nov;12(5):1012–1017. doi: 10.1128/iai.12.5.1012-1017.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Olsen G. A., Kern E. R., Glasgow L. A., Overall J. C. Effect of treatment with exogenous interferon, polyinosinic acid-polyctyidylic acid or polyinosinic acid-polycytidylic acid-poly-L-lysine complex on encephalomyocarditis virus infections in mice. Antimicrob Agents Chemother. 1976 Oct;10(4):668–676. doi: 10.1128/aac.10.4.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Overall J. C., Jr, Kern E. R., Glasgow L. A. Effective antiviral chemotherapy in cytomegalovirus infection of mice. J Infect Dis. 1976 Jun;133 (Suppl):A237–A244. doi: 10.1093/infdis/133.supplement_2.a237. [DOI] [PubMed] [Google Scholar]
  14. Postic B., Dowling J. N. Susceptibility of clinical isolates of cytomegalovirus to human interferon. Antimicrob Agents Chemother. 1977 Apr;11(4):656–660. doi: 10.1128/aac.11.4.656. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Worthington M., Baron S. Late therapy with an interferon stimulator in an arbovirus encephalitis in mice. Proc Soc Exp Biol Med. 1971 Jan;136(1):323–327. doi: 10.3181/00379727-136-35257. [DOI] [PubMed] [Google Scholar]

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