Abstract
To assess the possibility that non-aminoglycoside antibiotics may adversely affect the nephrotoxicity of the new semisynthetic aminoglycoside netilmicin, we gave ampicillin, carbenicillin, methicillin, cefamandole, and clindamycin, either singly or in combination with netilmicin, at two dose concentrations in rats. Results were compared as to the effect of netilmicin given singly and to saline-injected and noninjected controls. Antibiotic combinations resulted in no greater nephrotoxicity than did netilmicin alone. Netilmicin concentrations in renal tissue were high, and these levels were not consistently affected by the other drugs. The data suggest that in rats the nephrotoxicity of netilmicin is not affected adversely by the presence of non-aminoglycoside antibiotics.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (first of three parts). N Engl J Med. 1977 Mar 24;296(12):663–670. doi: 10.1056/NEJM197703242961205. [DOI] [PubMed] [Google Scholar]
- Bobrow S. N., Jaffe E., Young R. C. Anuria and acute tubular necrosis associated with gentamicin and cephalothin. JAMA. 1972 Dec 18;222(12):1546–1547. [PubMed] [Google Scholar]
- Butkus D. E., de Torrente A., Terman D. S. Renal failure following gentamicin in combination with clindamycin. Nephron. 1976;17(4):307–313. doi: 10.1159/000180735. [DOI] [PubMed] [Google Scholar]
- Dellinger P., Murphy T., Barza M., Pinn V., Weinstein L. Effect of cephalothin on renal cortical concentrations of gentamicin in rats. Antimicrob Agents Chemother. 1976 Apr;9(4):587–588. doi: 10.1128/aac.9.4.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dellinger P., Murphy T., Pinn V., Barza M., Weinstein L. Protective effect of cephalothin against gentamincin-induced nephrotoxicity in rats. Antimicrob Agents Chemother. 1976 Jan;9(1):172–178. doi: 10.1128/aac.9.1.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fillastre J. P., Laumonier R., Humbert G., Dubois D., Metayer J., Delpech A., Leroy J., Robert M. Acute renal failure associated with combined gentamicin and cephalothin therapy. Br Med J. 1973 May 19;2(5863):396–397. doi: 10.1136/bmj.2.5863.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harrison W. O., Silverblatt F. J., Turck M. Gentamicin nephrotoxicity: failure of three cephalosporins to potentiate injury in rats. Antimicrob Agents Chemother. 1975 Aug;8(2):209–215. doi: 10.1128/aac.8.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kleinknecht D., Ganeval D., Droz D. Acute renal failure after high doses of gentamicin and cephalothin. Lancet. 1973 May 19;1(7812):1129–1129. doi: 10.1016/s0140-6736(73)90447-9. [DOI] [PubMed] [Google Scholar]
- Luft F. C., Patel V., Yum M. N., Kleit S. A. Nephrotoxicity of cephalosporin-gentamicin combinations in rats. Antimicrob Agents Chemother. 1976 May;9(5):831–839. doi: 10.1128/aac.9.5.831. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Luft F. C., Yum M. N., Kleit S. A. Comparative nephrotoxicities of netilmicin and gentamicin in rats. Antimicrob Agents Chemother. 1976 Nov;10(5):845–849. doi: 10.1128/aac.10.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MARTINEZ E., DOOLAN P. D. Determination of creatinine in small quantities of plasma. Observations on two methods. Clin Chem. 1960 Jun;6:233–242. [PubMed] [Google Scholar]
- Patel V., Luft F. C., Yum M. N., Patel B., Zeman W., Kleit S. A. Enzymuria in gentamicin-induced kidney damage. Antimicrob Agents Chemother. 1975 Mar;7(3):364–369. doi: 10.1128/aac.7.3.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plager J. E. Association of renal injury with combined cephalothin-gentamicin therapy among patients severely ill with malignant disease. Cancer. 1976 Apr;37(4):1937–1943. doi: 10.1002/1097-0142(197604)37:4<1937::aid-cncr2820370445>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]