Abstract
Haemocin, a bacteriocin produced by Haemophilus influenzae b, caused pronounced cell elongation of the sensitive strains H. influenzae Rd and Escherichia coli CR34 thyA. In the sensitive strains, haemocin markedly inhibited the synthesis of deoxyribonucleic acid (DNA) but did not affect either ribonucleic acid or protein synthesis. The observed inhibition in synthesis of DNA was not due to degradation of preexisting DNA. The data suggest that haemocin may specifically inhibit DNA synthesis.
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- Fields K. L., Luria S. E. Effects of colicins E1 and K on cellular metabolism. J Bacteriol. 1969 Jan;97(1):64–77. doi: 10.1128/jb.97.1.64-77.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JACOB F., SIMINOVITCH L., WOLLMAN E. Sur la biosynthèse d'une colicine et sur son mode d'action. Ann Inst Pasteur (Paris) 1952 Sep;83(3):295–315. [PubMed] [Google Scholar]
- MASTER R. W. POSSIBLE SYNTHESIS OF POLYRIBONUCLEOTIDES OF KNOWN BASE-TRIPLET SEQUENCES. Nature. 1965 Apr 3;206:93–93. doi: 10.1038/206093b0. [DOI] [PubMed] [Google Scholar]
- NOMURA M. MECHANISM OF ACTION OF COLICINES. Proc Natl Acad Sci U S A. 1964 Dec;52:1514–1521. doi: 10.1073/pnas.52.6.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reeves P. Mode of action of colicins of types E1, E2, E3, and K. J Bacteriol. 1968 Nov;96(5):1700–1703. doi: 10.1128/jb.96.5.1700-1703.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Senior B. W., Kwasniak J., Holland I. B. Colicin E3-directed changes in ribosome function and polyribosome metabolism in Escherichia coli K12. J Mol Biol. 1970 Oct 28;53(2):205–220. doi: 10.1016/0022-2836(70)90295-0. [DOI] [PubMed] [Google Scholar]
- Venezia R. A., Matusiak P. M., Robertson R. G. Bactericidal factor produced by Haemophilus influenzae b: partial purification of the factor and transfer of its genetic determinant. Antimicrob Agents Chemother. 1977 Apr;11(4):735–742. doi: 10.1128/aac.11.4.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Venezia R. A., Robertson R. G. Bactericidal substance produced by Haemophilus influenzae b. Can J Microbiol. 1975 Oct;21(10):1587–1594. doi: 10.1139/m75-232. [DOI] [PubMed] [Google Scholar]