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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neuropharmacology. 2012 Aug 8;68:210–222. doi: 10.1016/j.neuropharm.2012.07.042

Figure 3. Cohort 3. Amphetamine impaired sociability on chamber time in control B6 mice and increased social sniffing in BTBR.

Figure 3

Replication was confirmed in a second independent cohort, tested by a different investigator. (A) The B6 control strain displayed normal sociability after saline treatment, but again did not show significant sociability after AMPH. (B) BTBR exhibited its characteristic lack of sociability after treatment with saline or AMPH. (C) B6 displayed sociability on the more sensitive parameter, time spent sniffing the novel mouse as compared to time spent sniffing the novel object, after both saline and AMPH. (D) BTBR exhibited its characteristic lack of sociability on the sniff parameter following saline vehicle administration. BTBR treated with AMPH exhibited significant sociability on the more sensitive sniff time parameter. *p < 0.05, novel mouse versus novel object. (E) B6 and (F) BTBR displayed more entries into the side chambers after treatment with AMPH than saline during the social approach task. *p < 0.05 AMPH 2.0 mg/kg i.p. versus SAL. N = 10–13 per dose for each strain in Cohort 3.