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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neuropharmacology. 2012 Aug 8;68:210–222. doi: 10.1016/j.neuropharm.2012.07.042

Figure 5. Amphetamine increased the number of sniffing bout events and reduced the duration of sniffing bouts in BTBR.

Figure 5

To quantitate the apparent qualitative difference in sniffing by BTBR treated with AMPH, which had been qualitatively apparent to observers, the number and duration of bout events of sniffing the novel mouse and novel object were scored over the 10 minute sociability session from videos of the social approach task. A representative sampling was created using sessions from the three independent cohorts. Videos were independently scored by three investigators, all uninformed of the drug treatment. For B6, (A) Number of discrete sniffing bouts, and (C) average duration of sniffing bouts did not differ in the AMPH versus saline treated groups. For BTBR, higher numbers of sniffing bouts occurred in mice treated with AMPH as compared to saline vehicle, and (D) the average duration of sniffing bouts was less in mice treated with AMPH compared to saline, indicative of many short sniffs in passing, rather than longer stationary exploratory sniffing of the novel mouse. *p < 0.02 AMPH 2.0 mg/kg i.p. as compared to SAL. N = 10 per dose for each strain.