Skip to main content
. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neuropharmacology. 2012 Aug 8;68:210–222. doi: 10.1016/j.neuropharm.2012.07.042

Figure 6. Amphetamine reduced normal levels of self-grooming in B6 and reduced the characteristically high levels of repetitive self-grooming in BTBR.

Figure 6

Cumulative time spent engaged in self-grooming behavior was scored over a 10 minute session, in three independent cohorts scored by three investigators blind to drug treatment. Cohort 2: (A) Robust reductions in the normally low levels of self-grooming in B6 mice were detected after AMPH as compared to saline vehicle. (B) BTBR displayed significant reductions in their innately high levels of repetitive self-grooming after AMPH. Cohort 3: AMPH significantly reduced self-grooming in (C) B6 and (D) BTBR. Cohort 4: AMPH significantly reduced self-grooming in (E) B6 and (F) BTBR. *p < 0.05 AMPH 2.0 mg/kg i.p. as compared to SAL. N = 9–14 per dose for each strain.