Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 Apr;13(4):605–607. doi: 10.1128/aac.13.4.605

Human Leukocyte Interferon in the Treatment of Varicella in Children with Cancer: a Preliminary Controlled Trial

Ann M Arvin 1, Sandor Feldman 2, Thomas C Merigan 1
PMCID: PMC352295  PMID: 352259

Abstract

Eighteen patients who developed varicella while being treated for malignancy received human leukocyte interferon in a randomized double-blind placebo-controlled trial. Complications of varicella occurred in six of nine placebo recipients, but in only two of nine interferon recipients. Interferon was tolerated without significant side effects.

Full text

PDF
605

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Feldman S., Hughes W. T., Daniel C. B. Varicella in children with cancer: Seventy-seven cases. Pediatrics. 1975 Sep;56(3):388–397. [PubMed] [Google Scholar]
  2. Gershon A. A., Steinberg S., Brunell P. A. Zoster immune globulin. A further assessment. N Engl J Med. 1974 Jan 31;290(5):243–245. doi: 10.1056/NEJM197401312900503. [DOI] [PubMed] [Google Scholar]
  3. Greenberg H. B., Pollard R. B., Lutwick L. I., Gregory P. B., Robinson W. S., Merigan T. C. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med. 1976 Sep 2;295(10):517–522. doi: 10.1056/NEJM197609022951001. [DOI] [PubMed] [Google Scholar]
  4. SCHMIDT N. J., LENNETTE E. H., SHON C. W., SHINOMOTO T. T. A COMPLEMENT-FIXING ANTIGEN FOR VARICELLA-ZOSTER DERIVED FROM INFECTED CULTURES OF HUMAN FETAL DIPLOID CELLS. Proc Soc Exp Biol Med. 1964 May;116:144–149. doi: 10.3181/00379727-116-29184. [DOI] [PubMed] [Google Scholar]
  5. Whitley R. J., Ch'ien L. T., Dolin R., Galasso G. J., Alford C. A., Jr Adenine arabinoside therapy of herpes zoster in the immunosuppressed. NIAID collaborative antiviral study. N Engl J Med. 1976 May 27;294(22):1193–1199. doi: 10.1056/NEJM197605272942201. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES