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. 1978 Apr;13(4):624–627. doi: 10.1128/aac.13.4.624

Factors Influencing Susceptibility of Nocardia Species to Trimethoprim-Sulfamethoxazole

John E Bennett 1, Anne E Jennings 2
PMCID: PMC352299  PMID: 352260

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams A. R., Jackson J. M., Scopa J., Lane G. K., Wilson R. Nocardiosis: diagnosis and management, with a report of three cases. Med J Aust. 1971 Mar 27;1(13):669–674. doi: 10.5694/j.1326-5377.1971.tb87784.x. [DOI] [PubMed] [Google Scholar]
  2. Baikie A. G., Macdonald C. B., Mundy G. R. Systemic nocardiosis treated with trimethoprim and sulphamethoxazole. Lancet. 1970 Aug 1;2(7666):261–261. doi: 10.1016/s0140-6736(70)92606-1. [DOI] [PubMed] [Google Scholar]
  3. Beaumont R. J. Trimethoprim as a possible therapy for nocardiosis and melioidosis. Med J Aust. 1970 Dec 12;2(24):1123–1127. doi: 10.5694/j.1326-5377.1970.tb63387.x. [DOI] [PubMed] [Google Scholar]
  4. Black W. A., McNellis D. A. Sensitivity of Nocardia to trimethoprim and sulphonamides in vitro. J Clin Pathol. 1970 Jul;23(5):423–426. doi: 10.1136/jcp.23.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. ELION G. B., SINGER S., HITCHINGS G. H. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. J Biol Chem. 1954 Jun;208(2):477–488. [PubMed] [Google Scholar]
  6. Havas L. Die Behandlung einiger tiefer Mykosen (z. B. südamerikanische Blastomykose, Nocardiose, Aktinomycetoma) mit dem Kombinationspräparat Sulfamethoxazol + Trimethoprim (Bactrim, Septrin)--Literaturübersicht. Mykosen. 1975 Jun;18(6):263–273. [PubMed] [Google Scholar]
  7. Kremer E. P. Pulmonary and cerebral nocardial abscess. Med J Aust. 1972 Sep 2;2(10):538–540. doi: 10.5694/j.1326-5377.1972.tb47462.x. [DOI] [PubMed] [Google Scholar]
  8. Maderazo E. G., Quintiliani R. Treatment of nocardial infection with trimethoprim and sulfamethoxazole. Am J Med. 1974 Oct;57(4):671–675. doi: 10.1016/0002-9343(74)90022-9. [DOI] [PubMed] [Google Scholar]
  9. Marcovitch H., Norman A. P. Treatment of nocardiosis. Lancet. 1970 Aug 15;2(7668):362–363. [PubMed] [Google Scholar]
  10. Pavillard E. R. Treatment of nocardial infection with trimethoprim-sulphamethoxazole. Med J Aust. 1973 Jun 30;1(2 Suppl):65–69. [PubMed] [Google Scholar]
  11. Pinkhas J., Oliver I., De Vries A., Spitzer S. A., Henig E. Pulmonary nocardiosis complicating malignant lymphoma successfully treated with chemotherapy. Chest. 1973 Mar;63(3):367–370. doi: 10.1378/chest.63.3.367. [DOI] [PubMed] [Google Scholar]
  12. Schwartz D. E., Ziegler W. H. Assay and pharmacokinetics of trimethoprim in man and animals. Postgrad Med J. 1969 Nov;45(Suppl):32–37. [PubMed] [Google Scholar]
  13. Wallace R. J., Jr, Septimus E. J., Musher D. M., Martin R. R. Disk diffusion susceptibility testing of Nocardia species. J Infect Dis. 1977 Apr;135(4):568–576. doi: 10.1093/infdis/135.4.568. [DOI] [PubMed] [Google Scholar]
  14. Whitman E. N. Effects in man of prolonged administration of trimethoprim and sulfisoxazole. Postgrad Med J. 1969 Nov;45(Suppl):46–51. [PubMed] [Google Scholar]

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