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. 1978 Apr;13(4):686–690. doi: 10.1128/aac.13.4.686

Inactivation of Herpes Simplex Viruses by Nonionic Surfactants

Samuel S Asculai 1,†, Margaret T Weis 1, Martha W Rancourt 1, A B Kupferberg 1,††
PMCID: PMC352310  PMID: 208460

Abstract

Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by observing surfactant destruction of mammalian cell plasma membranes and herpes simplex virus envelopes. Proprietary vaginal contraceptive formulations containing nonionic surfactants also inactivated herpes simplex virus infectivity. This observation suggests that nonionic surfactants in appropriate formulation could effectively prevent herpes simplex virus transmission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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