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. 1978 May;13(5):784–790. doi: 10.1128/aac.13.5.784

SK&F 75073, New Parenteral Broad-Spectrum Cephalosporin with High and Prolonged Serum Levels

Paul Actor 1, Joseph V Uri 1, Ihor Zajac 1, Joseph R Guarini 1, Lillian Phillips 1, Donald H Pitkin 1, David A Berges 1, George L Dunn 1, John R E Hoover 1, Jerry A Weisbach 1
PMCID: PMC352331  PMID: 96734

Abstract

SK&F 75073, a new parenteral cephalosporin, was found to have broad in vitro and in vivo antibacterial activity including isolates usually resistant to cephalothin and cefazolin. This activity included indole-positive Proteus and Enterobacter species and some Serratia isolates. Proteus mirabilis strains were particularly susceptible, as were Haemophilus influenzae and Neisseria species. The activity of SK&F 75073 against gram-positive bacteria was poorer than that of the control cephalosporins. This cephalosporin is highly bound to serum proteins, and a loss in in vitro activity was observed in the presence of serum. Parenteral administration of SK&F 75073 to experimental animals (mice, dogs, squirrel monkeys) resulted in high and prolonged serum levels when compared with cefazolin and other injectable cephalosporins. This favorable serum profile was reflected in the excellent protection observed in mice infected with pathogenic bacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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