Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 May;13(5):813–819. doi: 10.1128/aac.13.5.813

Synergy of Azlocillin and Mezlocillin Combined With Aminoglycoside Antibiotics and Cephalosporins

Harold C Neu 1,†, Kwung P Fu 1
PMCID: PMC352336  PMID: 666302

Abstract

Synergistic activity between both azlocillin and mezlocillin and aminoglycosides or cefazolin could be demonstrated by checkerboard dilution, isobologram, and killing curve techniques. Azlocillin and mezlocillin combined with gentamicin, netilmicin, or amikacin were synergistic against Escherichia coli, Klebsiella, Citrobacter, Enterobacter, Serratia, and indole-positive Proteus. Synergy was observed with isolates that were susceptible or resistant to azlocillin or mezlocillin. Synergy was seen most often when azlocillin or mezlocillin were combined with amikacin, gentamicin, or netilmicin against Pseudomonas aeruginosa. The combination of mezlocillin and an aminoglycoside produced synergy more often than did carbenicillin plus an aminoglycoside. No antagonism was seen when aminoglycoside antibiotics were combined with azlocillin or mezlocillin. Cefazolin was synergistic against Pseudomonas, Providencia, P. mirabilis, indole-positive Proteus, Citrobacter, Klebsiella, and Escherichia coli, when combined with azlocillin or mezlocillin. However, the combination of either agent with cefazolin was antagonistic when tested against selected indole-positive Proteus and Enterobacter isolates.

Full text

PDF
813

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (first of three parts). N Engl J Med. 1977 Mar 24;296(12):663–670. doi: 10.1056/NEJM197703242961205. [DOI] [PubMed] [Google Scholar]
  2. Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (second of three parts). N Engl J Med. 1977 Mar 31;296(13):722–728. doi: 10.1056/NEJM197703312961305. [DOI] [PubMed] [Google Scholar]
  3. Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (third of three parts). N Engl J Med. 1977 Apr 7;296(14):784–787. doi: 10.1056/NEJM197704072961404. [DOI] [PubMed] [Google Scholar]
  4. Fu K. P., Neu H. C. In vitro synergistic effect of netilmicin, a new aminoglycoside antibiotic. Antimicrob Agents Chemother. 1976 Sep;10(3):511–518. doi: 10.1128/aac.10.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Greenwood D., O'Grady F. Potent combinations of beta-lactam antibiotics using the beta-lactamase inhibition principle. Chemotherapy. 1975;21(6):330–341. doi: 10.1159/000221878. [DOI] [PubMed] [Google Scholar]
  6. Hamilton T. E., Lawrence P. J. The formation of functional penicillin-binding proteins. J Biol Chem. 1975 Aug 25;250(16):6578–6585. [PubMed] [Google Scholar]
  7. Neu J. C. Synergy of mecillinam, a beta-amidinopenicillanic acid derivative, combined with beta-lactam antibiotics. Antimicrob Agents Chemother. 1976 Sep;10(3):535–542. doi: 10.1128/aac.10.3.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Okubo T., Inoue M., Mitsuhashi S. Antibacterial activity of combinations of cefazolin and semisynthetic penicillins. J Antibiot (Tokyo) 1975 Oct;28(10):804–808. doi: 10.7164/antibiotics.28.804. [DOI] [PubMed] [Google Scholar]
  9. Parry M. G., Neu H. C. Ticarcillin for treatment of serious infections with gram-negative bacteria. J Infect Dis. 1976 Nov;134(5):476–485. doi: 10.1093/infdis/134.5.476. [DOI] [PubMed] [Google Scholar]
  10. Schimpff S., Satterlee W., Young V. M., Serpick A. Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med. 1971 May 13;284(19):1061–1065. doi: 10.1056/NEJM197105132841904. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES