Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 May;13(5):884–887. doi: 10.1128/aac.13.5.884

Characterization of a Small Plasmid Determining Resistance to Erythromycin, Lincomycin, and Vernamycin Bα in a Strain of Streptococcus sanguis Isolated from Dental Plaque

Yoshihiko Yagi 1, Thomas S McLellan 1, William A Frez 1, Don B Clewell 1
PMCID: PMC352349  PMID: 96738

Abstract

A plasmid determining resistance to erythromycin (inducible), lincomycin, and vernamycin Bα was isolated from a strain of Streptococcus sanguis isolated from dental plaque of a patient who had been on erythromycin therapy for an extended period of time. The plasmid, designated pAM77, had a molecular weight of 4.5 × 106 and was present to the extent of one to two copies per bacterial chromosome. The plasmid could transform S. sanguis strain Challis.

Full text

PDF
884

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker C. N., Thornsberry C. Antimicrobial susceptibility of Streptococcus mutans isolated from patients with endocarditis. Antimicrob Agents Chemother. 1974 Mar;5(3):268–271. doi: 10.1128/aac.5.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bazaral M., Helinski D. R. Characterization of multiple circular DNA forms of colicinogenic factor E-1 from Proteus mirabilis. Biochemistry. 1968 Oct;7(10):3513–3520. doi: 10.1021/bi00850a028. [DOI] [PubMed] [Google Scholar]
  3. Carlsson J. Presence of various types of non-haemolytic streptococci in dental plaque and in other sites of the oral cavity in man. Odontol Revy. 1967;18(1):55–74. [PubMed] [Google Scholar]
  4. Carlsson J. Zooglea-forming streptococci, resembling Streptococcus sanguis, isolated from dental plaque in man. Odontol Revy. 1965;16(4):348–358. [PubMed] [Google Scholar]
  5. Clewell D. B., Franke A. E. Characterization of a plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain Streptococcus pyogenes. Antimicrob Agents Chemother. 1974 May;5(5):534–537. doi: 10.1128/aac.5.5.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clewell D. B., Helinski D. R. Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry. 1970 Oct 27;9(22):4428–4440. doi: 10.1021/bi00824a026. [DOI] [PubMed] [Google Scholar]
  7. Clewell D. B. Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. J Bacteriol. 1972 May;110(2):667–676. doi: 10.1128/jb.110.2.667-676.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Clewell D. B., Yagi Y., Dunny G. M., Schultz S. K. Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance. J Bacteriol. 1974 Jan;117(1):283–289. doi: 10.1128/jb.117.1.283-289.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Clowes R. C. Molecular structure of bacterial plasmids. Bacteriol Rev. 1972 Sep;36(3):361–405. doi: 10.1128/br.36.3.361-405.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Courvalin P. M., Carlier C., Chabbert Y. A. Plasmid-linked tetracycline and erythromycin resistance in group D "streptococcus". Ann Inst Pasteur (Paris) 1972 Dec;123(6):755–759. [PubMed] [Google Scholar]
  11. Courvalin P. M., Carlier C., Croissant O., Blangy D. Identification of two plasmids determining resistance to tetracycline and to erythromycin in group D streptococcus. Mol Gen Genet. 1974;132(3):181–192. doi: 10.1007/BF00269391. [DOI] [PubMed] [Google Scholar]
  12. Davidson J. R., Jr, Blevins W. T., Feary T. W. Interspecies transformation of streptomycin resistance in oral streptococci. Antimicrob Agents Chemother. 1976 Jan;9(1):145–150. doi: 10.1128/aac.9.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Dunny G. M., Clewell D. B. Transmissible toxin (hemolysin) plasmid in Streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid. J Bacteriol. 1975 Nov;124(2):784–790. doi: 10.1128/jb.124.2.784-790.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Guggenheim B. Streptococci of dental plaques. Caries Res. 1968;2(2):147–163. doi: 10.1159/000259553. [DOI] [PubMed] [Google Scholar]
  15. Horodniceanu T., Bouanchaud D. H., Bieth G., Chabbert Y. A. R plasmids in Streptococcus agalactiae (group B). Antimicrob Agents Chemother. 1976 Nov;10(5):795–801. doi: 10.1128/aac.10.5.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Jacob A. E., Hobbs S. J. Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes. J Bacteriol. 1974 Feb;117(2):360–372. doi: 10.1128/jb.117.2.360-372.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. LeBlanc D. J., Hassell F. P. Transformation of Streptococcus sanguis Challis by plasmid deoxyribonucleic acid from Streptococcus faecalis. J Bacteriol. 1976 Oct;128(1):347–355. doi: 10.1128/jb.128.1.347-355.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Macrina F. L., Reider J. L., Virgili S. S., Kopecko D. J. Survey of the extrachromosomal gene pool of Streptococcus mutans. Infect Immun. 1977 Jul;17(1):215–226. doi: 10.1128/iai.17.1.215-226.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Malke H., Jacob H. E., Störl K. Characterization of the antibiotic resistance plasmid ERL1 from Streptococcus pyogenes. Mol Gen Genet. 1976 Mar 30;144(3):333–338. doi: 10.1007/BF00341732. [DOI] [PubMed] [Google Scholar]
  21. Nakae M., Inoue M., Mitsuhashi S. Artificial elimination of drug resistance from group A beta-hemolytic streptococci. Antimicrob Agents Chemother. 1975 May;7(5):719–720. doi: 10.1128/aac.7.5.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Niven C. F., Kiziuta Z., White J. C. Synthesis of a Polysaccharide from Sucrose by Streptococcus S.B.E. J Bacteriol. 1946 Jun;51(6):711–716. doi: 10.1128/jb.51.6.711-716.1946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sprunt K., Redman W., Leidy G. Penicillin resistant alpha Streptococci in pharynx of patients given oral penicillin. Pediatrics. 1968 Dec;42(6):957–968. [PubMed] [Google Scholar]
  24. Watase R. K., Bahn A. N., Haga C. Penicillin-resistant streptococci from the saliva. J Dent Res. 1966 Mar-Apr;45(2):243–248. doi: 10.1177/00220345660450020501. [DOI] [PubMed] [Google Scholar]
  25. Yag Y., Franke A. E., Clewell D. B. Plasmid-determined resistance to erythromycin: comparison of strains of streptococcus faecalis and streptococcus pyogenes with regard to plasmid hmology and resistance inducibility. Antimicrob Agents Chemother. 1975 Jun;7(6):871–873. doi: 10.1128/aac.7.6.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Yagi Y., Clewell D. B. Plasmid-determined tetracycline resistance in Streptococcus faecalis: tandemly repeated resistance determinants in amplified forms of pAMalpha1 DNA. J Mol Biol. 1976 Apr 15;102(3):583–600. doi: 10.1016/0022-2836(76)90336-3. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES