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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 May;13(5):891–892. doi: 10.1128/aac.13.5.891

In Vitro Evaluation of a Semisynthetic Derivative of Gentamicin B (SCH 21420)

Pauline K W Yu 1, John A Washington II 1
PMCID: PMC352351  PMID: 666309

Abstract

The activities of Sch 21420 and amikacin were compared in vitro against 448 clinical bacterial isolates and against 82 gentamicin-resistant isolates of gram-negative bacilli. At 1 μg/ml, Sch 21420 was more active than amikacin against most Enterobacteriaceae but less active against Pseudomonas aeruginosa. Activity of these antibiotics against gentamicin-resistant organisms varied according to the species examined.

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