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. 1978 Jun;13(6):939–943. doi: 10.1128/aac.13.6.939

Effect of an Interferon Inducer, 9-Methylstreptimidone, on Candida albicans Infection in Mice

Takusei Umenai 1, Fujio Suzuki 1, Nakao Ishida 1
PMCID: PMC352366  PMID: 354522

Abstract

The protective effect of an interferon inducer with a low molecular weight, 9-methylstreptimidone (9-MS), against Candida albicans infection in mice was investigated. The antibiotic was effective only when given prophylactically. When administered in such a manner, the growth of C. albicans in the kidneys and brain was inhibited at the initial stage of infection. The growth of C. albicans was not inhibited by the antibiotic in vitro, and no antifungal effect was obtained in a preparation containing induced interferon. These results suggest that the antifungal action of 9-methylstreptimidone in mice might be manifested not by direct antifungal activity but rather by a host-mediated activity that excludes interferon-inducing capability.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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