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. 1978 Jun;13(6):979–984. doi: 10.1128/aac.13.6.979

Effect of Triethylenetetramine Dihydrochloride on the Antibiotic Susceptibility of Pseudomonas aeruginosa

B Light 1, H G Riggs Jr 1
PMCID: PMC352375  PMID: 98108

Abstract

A chelating agent, triethylenetetramine dihydrochloride, interacted synergistically in vitro with both gentamicin and carbenicillin against a clinical isolate of Pseudomonas aeruginosa designated Ps 15. The minimal inhibitory concentrations of carbenicillin and gentamicin for Ps 15 in a 50% serum-Trypticase soy broth were 250 and 72.9 μg/ml, respectively. However, addition of triethylenetetramine dihydrochloride to the 50% serum-Trypticase soy broth reduced the minimal inhibitory concentration of both antibiotics approximately 10-fold. A comparison of the growth of Ps 15 in 50% serum-Trypticase soy broth containing either of the antibiotics showed that a rapid decrease in the percentage of survivors only occurred when the chelating agent was present.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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