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. 1978 Jul;14(1):69–72. doi: 10.1128/aac.14.1.69

Enzymatic Modification of Aminoglycoside Antibiotics: 3-N-Acetyltransferase with Broad Specificity that Determines Resistance to the Novel Aminoglycoside Apramycin

Julian Davies 1, Sean O'Connor 2
PMCID: PMC352406  PMID: 356726

Abstract

Examination of a number of R-plasmid-containing bacterial isolates of animal origin has revealed the presence of a new aminoglycoside acetyltransferase (3-N) with a broad substrate range that includes all the disubstituted 2-deoxystreptamine antibiotics and also the novel monosubstituted antibiotic apramycin. Antibiotic derivatives acylated with hydroxyaminobutyric acid at the 1-amino position were not modified by the enzyme.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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