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. 1978 Jul;14(1):73–77. doi: 10.1128/aac.14.1.73

Antibiotic Biosynthesis by Cofermentation of Blocked Mutants of Two Micromonospora Species

B K Lee 1, T L Nagabhushan 1, R G Condon 1, A B Cooper 1, J A Waitz 1
PMCID: PMC352407  PMID: 686710

Abstract

Two aminocyclitol-negative Micromonospora mutants representing two different species, M. purpurea and M. inyoensis, and blocked at different steps in the biosynthetic pathway were paired and cofermented for the synthesis of antibiotics. The two blocked mutants were incapable of producing antibiotics alone except when 2-deoxystreptamine was added. When combined they produced gentamicins A, X2, C1a, and C2b, which all have an amino group at the 2′ position, and gentamicin B, which has a hydroxyl group at this position instead.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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