Abstract
The in vitro inhibitory activity of rosamicin and erythromycin against 283 strains of nonfermenting, gram-negative bacilli was determined by using a broth dilution procedure. Rosamicin demonstrated greater activity than erythromycin against most strains tested. A number of species demonstrated significantly lower minimum inhibitory concentrations to rosamicin and would fall within the therapeutic range of the drug based on current pharmacological data.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baumueller A., Hoyme U., Madsen P. O. Rosamicin--a new drug for the treatment of bacterial prostatitis. Antimicrob Agents Chemother. 1977 Aug;12(2):240–242. doi: 10.1128/aac.12.2.240. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crowe C. C., Sanders W. E., Jr Rosamicin: evaluation in vitro and comparison with erythromycin and lincomycin. Antimicrob Agents Chemother. 1974 Mar;5(3):272–275. doi: 10.1128/aac.5.3.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoyme U., Baumueller A., Madsen P. O. Rosamicin in urethral and vaginal secretions and tissues in dogs and rats. Antimicrob Agents Chemother. 1977 Aug;12(2):237–239. doi: 10.1128/aac.12.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanders C. C., Sanders W. E., Jr In vitro activity of rosamicin against Neisseria and Haemophilus, including penicillinase-producing strains. Antimicrob Agents Chemother. 1977 Aug;12(2):293–294. doi: 10.1128/aac.12.2.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Santoro J., Kaye D., Levison M. E. In vitro activity of josamycin and rosamicin against Bacteroides fragilis compared with clindamycin, erythromycin, and metronidazole. Antimicrob Agents Chemother. 1976 Jul;10(1):188–190. doi: 10.1128/aac.10.1.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shadomy S., Tipple M., Paxton L. Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin. Antimicrob Agents Chemother. 1976 Oct;10(4):773–775. doi: 10.1128/aac.10.4.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutter V. L., Finegold S. M. Rosamicin: in vitro activity against anaerobes and comparison with erythromycin. Antimicrob Agents Chemother. 1976 Feb;9(2):350–351. doi: 10.1128/aac.9.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wagman G. H., Waitz J. A., Marquez J., Murawaski A., Oden E. M., Testa R. T., Weinstein M. J. A new Micromonospora-produced macrolide antibiotic, rosamicin. J Antibiot (Tokyo) 1972 Nov;25(11):641–646. doi: 10.7164/antibiotics.25.641. [DOI] [PubMed] [Google Scholar]
- Waitz J. A., Drube C. G., Moss E. L., Jr, Weinstein M. J. Biological studies with rosamicin, a new Micromonospora-produced macrolide antibiotic. J Antibiot (Tokyo) 1972 Nov;25(11):647–652. doi: 10.7164/antibiotics.25.647. [DOI] [PubMed] [Google Scholar]