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. 1978 Sep;14(3):344–347. doi: 10.1128/aac.14.3.344

Effects of Hypoxemia upon Aminoglycoside Serum Pharmacokinetics in Animals

Najwa J Mirhij 1, Robert J Roberts 1, Martin G Myers 1
PMCID: PMC352462  PMID: 708011

Abstract

Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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