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. 1978 Sep;14(3):398–402. doi: 10.1128/aac.14.3.398

Amphotericin B and 5-Fluorocytosine: In Vitro Effects on Lymphocyte Function

Gary A Roselle 1, Carol A Kauffman 2
PMCID: PMC352471  PMID: 708017

Abstract

The effects of amphotericin B, 5-fluorocytosine, and the combination of both drugs on lymphocyte function in vitro were investigated. Amphotericin B, alone or in combination with 5-fluorocytosine, significantly suppressed both spontaneous lymphocyte transformation and the response of lymphocytes to stimulation with streptokinase-streptodornase. 5-Fluorocytosine had no effect on spontaneous or antigen-induced transformation. Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A were not changed by exposure to amphotericin B, 5-fluorocytosine, or the combination of both drugs. T-lymphocyte receptors for sheep erythrocytes and B-lymphocyte surface immunoglobulin and receptors for complement were not changed by treatment with amphotericin B or 5-fluorocytosine.

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Selected References

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