Abstract
The in vitro activity of thienamycin was tested against 135 aerobic and anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli and penicillin-resistant Straphylococcus aureus. The antianaerobic spectrum of the drug seemed to be comparable to that of metronidazole.
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Selected References
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- Ernst E. C., Berger S., Barza M., Jacobus N. V., Tally F. P. Activity of cefamandole and other cephalosporins against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1976 May;9(5):852–855. doi: 10.1128/aac.9.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Finegold S. M. Therapy for infections due to anaerobic bacteria: an overview. J Infect Dis. 1977 Mar;135 (Suppl):S25–S29. doi: 10.1093/infdis/135.supplement.s25. [DOI] [PubMed] [Google Scholar]
- Salaki J. S., Black R., Tally F. P., Kislak J. W. Bacteroides fragilis resistant to the administration of clindamycin. Am J Med. 1976 Mar;60(3):426–428. doi: 10.1016/0002-9343(76)90759-2. [DOI] [PubMed] [Google Scholar]
- Spratt B. G., Jobanputra V., Zimmermann W. Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12. Antimicrob Agents Chemother. 1977 Sep;12(3):406–409. doi: 10.1128/aac.12.3.406. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sutter V. L., Finegold S. M. Susceptibility of anaerobic bacteria to 23 antimicrobial agents. Antimicrob Agents Chemother. 1976 Oct;10(4):736–752. doi: 10.1128/aac.10.4.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tally F. P., Jacobus N. V., Bartlett J. G., Gorbach S. L. Susceptibility of anaerobes to cefoxitin and other cephalosporins. Antimicrob Agents Chemother. 1975 Feb;7(2):128–132. doi: 10.1128/aac.7.2.128. [DOI] [PMC free article] [PubMed] [Google Scholar]