Abstract
To determine the efficacy of single-dose doxycycline in the treatment of cholera, we carried out a randomized prospective trial in 65 patients. Treatment consisted of either a single dose of 200 mg of doxycycline (or 4 mg/kg in patients less than 15 years old) or multiple doses of doxycycline, 500 mg over 4 days (or 10 mg/kg in patients less than 15 years old). There were no differences between the groups in the volumes of intravenous fluid required, volumes of diarrheal stool, or durations of diarrhea. The mean duration of positive stool cultures for Vibrio cholerae was similar for the two groups, although in both groups several patients continued to excrete Vibrios in the stool for more than 3 days. Blood levels of antibiotic demonstrated that the doxycycline was absorbed in spite of the rapid transit time associated with severe diarrhea. These results suggest that although tetracycline remains the drug of choice for cholera, doxycycline is a reasonable alternative, and that a single dose of 200 mg (4 mg/kg in children) is effective clinically.
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Selected References
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- Cash R. A., Toha K. M., Nalin D. R., Huq Z., Phillips R. A. Acetate in the correction of acidosis secondary to diarrhoea. Lancet. 1969 Aug 9;2(7615):302–303. doi: 10.1016/s0140-6736(69)90060-9. [DOI] [PubMed] [Google Scholar]
- De S., Chaudhuri A., Dutta P., Dutta D., De S. P., Pal S. C. Doxycycline in the treatment of cholera. Bull World Health Organ. 1976;54(2):177–179. [PMC free article] [PubMed] [Google Scholar]
- Lindenbaum J., Greenough W. B., Islam M. R. Antibiotic therapy of cholera. Bull World Health Organ. 1967;36(6):871–883. [PMC free article] [PubMed] [Google Scholar]
- Rahaman M. M., Majid M. A., Alam AKMJ, Islam M. R. Effects of doxycycline in actively purging cholera patients: a double-blind clinical trial. Antimicrob Agents Chemother. 1976 Oct;10(4):610–612. doi: 10.1128/aac.10.4.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wallace C. K., Anderson P. N., Brown T. C., Khanra S. R., Lewis G. W., Pierce N. F., Sanyal S. N., Segre G. V., Waldman R. H. Optimal antibiotic therapy in cholera. Bull World Health Organ. 1968;39(2):239–245. [PMC free article] [PubMed] [Google Scholar]
- Woodward W. E., Mosley W. H. The spectrum of cholera in rural Bangladesh. II. Comparison of El Tor Ogawa and classical Inaba infection. Am J Epidemiol. 1972 Nov;96(5):342–351. doi: 10.1093/oxfordjournals.aje.a121465. [DOI] [PubMed] [Google Scholar]