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. 1978 Sep;14(3):465–469. doi: 10.1128/aac.14.3.465

Combined Activity of Minocycline and Amphotericin B In Vitro Against Medically Important Yeasts

Michael A Lew 1, Kevin M Beckett 1, Myron J Levin 1
PMCID: PMC352483  PMID: 708025

Abstract

The capacity of minocycline to enhance the activity of amphotericin B against Candida albicans, Torulopsis glabrata, Cryptococcus neoformans, and non-albicans Candida was examined in vitro utilizing a time-killing curve technique. Synergism was apparent at 4 h with 5 of 5 strains of C. albicans, 8 of 8 strains of C. neoformans, and 1 of 12 strains of non-albicans Candida. Synergism was apparent at 24 h with the remaining 11 strains of non-albicans Candida and all 5 strains of T. glabrata. C. neoformans was the most susceptible of the yeasts to the minocycline-amphotericin B combination; seven strains showed a 3-log or greater reduction in colony count in 4 h and all strains showed this reduction in 24 h at amphotericin B concentrations of 0.4 μg/ml or less in the presence of minocycline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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