Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1978 Sep;14(3):493–494. doi: 10.1128/aac.14.3.493

In Vitro Susceptibility of 30 Strains of Chlamydia trachomatis to Rosamicin

Thomas F Smith 1, Harriet E Washton 2
PMCID: PMC352488  PMID: 708027

Abstract

A total of 13 of 30 clinical isolates of Chlamydia trachomatis were susceptible in vitro to 0.01 μg of rosamicin per ml. Only two of these strains were susceptible to tetracycline or erythromycin at this level. The results suggest that rosamicin may be useful for the treatment of chlamydial urethritis.

Full text

PDF
493

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERNKOPF H., MASHIAH P., BECKER Y. Susceptibility of a trachoma agent grown in FL cell cultures to antibiotics and a sulfa drug. Proc Soc Exp Biol Med. 1962 Oct;111:61–67. doi: 10.3181/00379727-111-27706. [DOI] [PubMed] [Google Scholar]
  2. Baumueller A., Hoyme U., Madsen P. O. Rosamicin--a new drug for the treatment of bacterial prostatitis. Antimicrob Agents Chemother. 1977 Aug;12(2):240–242. doi: 10.1128/aac.12.2.240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blackman H. J., Yoneda C., Dawson C. R., Schachter J. Antibiotic susceptibility of Chlamydia trachomatis. Antimicrob Agents Chemother. 1977 Dec;12(6):673–677. doi: 10.1128/aac.12.6.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gordon F. B., Quan A. L. Susceptibility of Chlamydia to antibacterial drugs: test in cell cultures. Antimicrob Agents Chemother. 1972 Sep;2(3):242–244. doi: 10.1128/aac.2.3.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
  6. Hoyme U., Baumueller A., Madsen P. O. Rosamicin in urethral and vaginal secretions and tissues in dogs and rats. Antimicrob Agents Chemother. 1977 Aug;12(2):237–239. doi: 10.1128/aac.12.2.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JAWETZ E., HANNA L. Trachoma viruses isolated in the United States. 3. Strain specific effects of tetracycline and penicillin. Proc Soc Exp Biol Med. 1960 Nov;105:320–323. doi: 10.3181/00379727-105-26097. [DOI] [PubMed] [Google Scholar]
  8. Johnson F. W., Hobson D. The effect of penicillin on genital strains of Chlamydia trachomatis in tissue culture. J Antimicrob Chemother. 1977 Jan;3(1):49–56. doi: 10.1093/jac/3.1.49. [DOI] [PubMed] [Google Scholar]
  9. Kuo C. C., Wang S. P., Grayston J. T. Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture. Antimicrob Agents Chemother. 1977 Jul;12(1):80–83. doi: 10.1128/aac.12.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. POLLARD M., TANAMI Y. Effects of antibiotics on trachoma virus in tissu cultures. Proc Soc Exp Biol Med. 1961 Jul;107:508–511. doi: 10.3181/00379727-107-26670. [DOI] [PubMed] [Google Scholar]
  11. Ridgway G. L., Owen J. M., Oriel J. D. A method for testing the antibiotic susceptibility of Chlamydia trachomatis in a cell culture system. J Antimicrob Chemother. 1976 Mar;2(1):71–76. doi: 10.1093/jac/2.1.71. [DOI] [PubMed] [Google Scholar]
  12. Sanders C. C., Sanders W. E., Jr In vitro activity of rosamicin against Neisseria and Haemophilus, including penicillinase-producing strains. Antimicrob Agents Chemother. 1977 Aug;12(2):293–294. doi: 10.1128/aac.12.2.293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Santoro J., Kaye D., Levison M. E. In vitro activity of josamycin and rosamicin against Bacteroides fragilis compared with clindamycin, erythromycin, and metronidazole. Antimicrob Agents Chemother. 1976 Jul;10(1):188–190. doi: 10.1128/aac.10.1.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shadomy S., Tipple M., Paxton L. Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin. Antimicrob Agents Chemother. 1976 Oct;10(4):773–775. doi: 10.1128/aac.10.4.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shiao L. C., Wang S. P., Grayston J. T. Sensitivity and resistance of TRIC agents to penicillin, tetracycline and sulfa drugs. Am J Ophthalmol. 1967 May;63(5 Suppl):1558–1568. doi: 10.1016/0002-9394(67)94147-5. [DOI] [PubMed] [Google Scholar]
  16. Smith T. F., Weed L. A., Segura J. W., Pettersen G. R., Washington JA I. I. Isolation of Chlamydia from patients with urethritis. Mayo Clin Proc. 1975 Mar;50(3):105–110. [PubMed] [Google Scholar]
  17. Sutter V. L., Finegold S. M. Rosamicin: in vitro activity against anaerobes and comparison with erythromycin. Antimicrob Agents Chemother. 1976 Feb;9(2):350–351. doi: 10.1128/aac.9.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES