Abstract
By multiple criteria, inosiplex—a reputed stimulator of virus-sensitized lymphocytes—had no demonstrable therapeutic effects in a preliminary controlled study of patients with localized herpes zoster and cancer. Lymphocytes from the six drug-treated patients were no more responsive to varicella-zoster antigen and phytohemagglutinin than were lymphocytes from seven patients who received a placebo.
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Selected References
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- Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J Exp Med. 1971 May 1;133(5):1090–1104. doi: 10.1084/jem.133.5.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J Exp Med. 1970 Nov;132(5):1035–1054. doi: 10.1084/jem.132.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med. 1971 May 1;133(5):1074–1089. doi: 10.1084/jem.133.5.1074. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradshaw L. J., Sumner H. L. In vitro studies on cell-mediated immunity in patients treated with inosiplex for herpes virus infection. Ann N Y Acad Sci. 1977 Mar 4;284:190–196. doi: 10.1111/j.1749-6632.1977.tb21950.x. [DOI] [PubMed] [Google Scholar]
- Dent P. B., Larke R. P. Viral infection and immunity. Med Clin North Am. 1972 Mar;56(2):353–370. doi: 10.1016/s0025-7125(16)32401-4. [DOI] [PubMed] [Google Scholar]
- Feldman S., Chaudary S., Ossi M., Epp E. A viremic phase for herpes zoster in children with cancer. J Pediatr. 1977 Oct;91(4):597–600. doi: 10.1016/s0022-3476(77)80509-x. [DOI] [PubMed] [Google Scholar]
- Feldman S., Hughes W. T., Darlington R. W., Kim H. K. Evaluation of topical polyinosinic acid-polycytidylic acid in treatment of localized herpes zoster in children with cancer: a randomized, double-blind controlled study. Antimicrob Agents Chemother. 1975 Sep;8(3):289–294. doi: 10.1128/aac.8.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ginsberg T., Glasky A. J. Inosiplex: an immunomodulation model for the treatment of viral disease. Ann N Y Acad Sci. 1977 Mar 4;284:128–138. doi: 10.1111/j.1749-6632.1977.tb21944.x. [DOI] [PubMed] [Google Scholar]
- Glasgow L. A. Cellular immunity in host resistance to viral infections. Arch Intern Med. 1970 Jul;126(1):125–134. [PubMed] [Google Scholar]
- Gordon P., Ronsen B., Brown E. R. Anti-herpesvirus action of isoprinosine. Antimicrob Agents Chemother. 1974 Feb;5(2):153–160. doi: 10.1128/aac.5.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hadden J. W., Hadden E. M., Coffey R. G. Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation. Infect Immun. 1976 Feb;13(2):382–387. doi: 10.1128/iai.13.2.382-387.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Longley S., Dunning R. L., Waldman R. H. Effect of isoprinosine against challenge with A(H3N2)-Hong Kong influenza virus in volunteers. Antimicrob Agents Chemother. 1973 Apr;3(4):506–509. doi: 10.1128/aac.3.4.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waldman R. H., Ganguly R. Therapeutic efficacy of inosiplex (Isoprinosine) in rhinovirus infection. Ann N Y Acad Sci. 1977 Mar 4;284:153–160. doi: 10.1111/j.1749-6632.1977.tb21946.x. [DOI] [PubMed] [Google Scholar]
