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. 1978 Oct;14(4):625–627. doi: 10.1128/aac.14.4.625

Effect of β-Lactam Antibiotics on In Vitro Peptidoglycan Cross-Linking by a Particulate Fraction from Escherichia coli K-12 and Bacillus megaterium KM

Tetsuo Oka 1, Hironori Fujita 1
PMCID: PMC352518  PMID: 102248

Abstract

The binding constants of several β-lactam antibiotics towards penicillin-binding components in Escherichia coli K-12 (Spratt, Eur. J. Biochem. 72:341–352, 1977) and the antibiotic concentrations required to inhibit the peptidoglycan transpeptidase of E. coli 50% were compared. Penicillin-binding component 1B may have been the transpeptidase working in vitro. The structure-activity relationships of β-lactam antibiotics and the mechanisms of action in E. coli and Bacillus megaterium are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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