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. 1978 Nov;14(5):791–793. doi: 10.1128/aac.14.5.791

Activity of Derivatives and Analogs of Dapsone Against Mycobacterium leprae

Louis Levy 1,
PMCID: PMC352553  PMID: 727767

Abstract

Of 25 dapsone derivatives and analogs screened for activity against Mycobacterium leprae in the mouse footpad system, only 7 were active. All seven were metabolized to or contaminated with dapsone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRODIE B. B., GILLETTE J. R., LA DU B. N. Enzymatic metabolism of drugs and other foreign compounds. Annu Rev Biochem. 1958;27(3):427–454. doi: 10.1146/annurev.bi.27.070158.002235. [DOI] [PubMed] [Google Scholar]
  2. Ellard G. A. Absorption, metabolism and excretion of di(rho-aminophenyl) sulphone (dapsone) and di(rho-aminophenyl) sulphoxide in man. Br J Pharmacol Chemother. 1966 Jan;26(1):212–217. doi: 10.1111/j.1476-5381.1966.tb01823.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ellard G. A., Gammon P. T., Rees R. J. The minimal inhibitory concentrations of sulphadimethozine and sulphadoxine against Mycobacterium leprae. Lepr Rev. 1970 Oct;41(4):223–228. doi: 10.5935/0305-7518.19700031. [DOI] [PubMed] [Google Scholar]
  4. Gaugas J. M. Antimicrobial therapy of experimental human leprosy (Myco. leprae) infection in the mouse foot pad. Lepr Rev. 1967 Oct;38(4):225–230. doi: 10.5935/0305-7518.19670037. [DOI] [PubMed] [Google Scholar]
  5. Gleason L. N., Vogh B. P. Deformylation of 4,4'-diformamidodiphenyl sulfone (DFD) by plasma of certain mammals. Biochem Pharmacol. 1971 Sep;20(9):2409–2416. doi: 10.1016/0006-2952(71)90241-3. [DOI] [PubMed] [Google Scholar]
  6. KARLSON A. G. THE IN VIRTO ACTIVITY OF 4,4'-DIAMINODIPHENYL SULFONE AGAINST VARIOUS ACID-FAST MICROORGANISMS. Int J Lepr. 1963 Apr-Jun;31:183–187. [PubMed] [Google Scholar]
  7. Levy L., Biggs J. T., Jr, Gordon G. R., Peters J. H. Disposition of the antileprosy drug, dapsone, in the mouse. Proc Soc Exp Biol Med. 1972 Jul;140(3):937–943. doi: 10.3181/00379727-140-36584. [DOI] [PubMed] [Google Scholar]
  8. Ozawa T., Shepard C. C., Karat A. B. Application of spectrophotofluorometric procedures to some problems in Mycobacterium leprae infections in mice and man treated with dapsone (DDS), diacetyl-DDS (DADDS), and di-formyl-DDS (DFD). Am J Trop Med Hyg. 1971 Mar;20(2):274–281. doi: 10.4269/ajtmh.1971.20.274. [DOI] [PubMed] [Google Scholar]
  9. Panitch M., Levy L. The action of dapsone on a susceptible strain of Mycobacterium kansasii. Lepr Rev. 1978 Jun;49(2):131–140. doi: 10.5935/0305-7518.19780016. [DOI] [PubMed] [Google Scholar]
  10. Pattyn S. R., van Ermengem J. DDS sensitivity of mycobacteria. Antagonistic effect of PABA for M. ulcerans and M. kansasii. Int J Lepr Other Mycobact Dis. 1968 Oct-Dec;36(4):427–431. [PubMed] [Google Scholar]
  11. Peters J. H., Gordon G. R., Murray J. F., Jr, Fieldsteel A. H., Levy L. Minimal inhibitory concentration of dapsone for Mycobacterium leprae in rats. Antimicrob Agents Chemother. 1975 Nov;8(5):551–557. doi: 10.1128/aac.8.5.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rees R. J. Recent bacteriologic, immunologic and pathologic studies on experimental human leprosy in the mouse foot pad. Int J Lepr. 1965 Jul-Sep;33(3 Suppl):646–657. [PubMed] [Google Scholar]
  13. Shepard C. C. Activity of repository sulfones against Mycobacterium leprae in mice. Proc Soc Exp Biol Med. 1967 Feb;124(2):430–433. doi: 10.3181/00379727-124-31757. [DOI] [PubMed] [Google Scholar]
  14. Shepard C. C. Further experience with the kinetic method for the study of drugs against Mycobacterium leprae in mice. Activities of DDS, DFD, ethionamide, capreomycin and PAM 1392. Int J Lepr Other Mycobact Dis. 1969 Oct-Dec;37(4):389–397. [PubMed] [Google Scholar]
  15. Shepard C. C., McRae D. H. A method for counting acid-fast bacteria. Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):78–82. [PubMed] [Google Scholar]

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