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. 1978 Nov;14(5):794–796. doi: 10.1128/aac.14.5.794

Inhibition of β-Lactamase in Neisseria gonorrhoeae by Sodium Clavulanate

J Michael Miller 1, Carolyn N Baker 1, Clyde Thornsberry 1
PMCID: PMC352554  PMID: 103496

Abstract

Sodium clavulanate at subinhibitory concentrations affected the activity of penicillin G, ampicillin, or amoxicillin on β-lactamase-positive strains of Neisseria gonorrhoeae as demonstrated by marked reduction in the minimal inhibitory concentrations of the drugs for the organisms. The compound did not affect the activity of these penicillins on β-lactamase-negative strains of N. gonorrhoeae. It also had no effect on the activity of cefoxitin against either β-lactamase-negative or -positive strains. The reduction in minimal inhibitory concentrations of the penicillins for the β-lactamase-positive organisms brought about by sodium clavulanate is probably due to inhibition of the β-lactamase by the compound.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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