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. 1978 Dec;14(6):842–845. doi: 10.1128/aac.14.6.842

Effect of 9-(2-Hydroxyethoxymethyl)guanine on Herpesvirus-Induced Keratitis and Iritis in Rabbits

Herbert E Kaufman 1, Emily D Varnell 1, Ysolina M Centifanto 1, Stephen D Rheinstrom 1
PMCID: PMC352567  PMID: 217301

Abstract

Drugs used for the inhibition of DNA viruses, such as iododeoxyuridine, adenine arabinoside, or trifluorothymidine, are not biochemically selective in their action and also interfere with normal cellular functions. The recently reported 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) is selectively phosphorylated by viral thymidine kinase but not by normal cellular thymidine kinase. Our present studies show that the acycloguanosine is as effective in treating herpetic keratitis in the rabbit as iododeoxyuridine and trifluorothymidine when given topically as an ointment. It is also effective when given intravenously for the treatment of herpetic iritis and is effective in preventing death from encephalitis in rabbits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abel R., Jr, Kaufman H. E., Sugar J. Intravenous adenine arabinoside against herpes simplex keratouveitis in humans. Am J Ophthalmol. 1975 Apr;79(4):659–664. doi: 10.1016/0002-9394(75)90807-7. [DOI] [PubMed] [Google Scholar]
  2. Elion G. B., Furman P. A., Fyfe J. A., de Miranda P., Beauchamp L., Schaeffer H. J. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5716–5720. doi: 10.1073/pnas.74.12.5716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Greer S., Schildkraut I., Zimmerman T., Kaufman H. 5-Halogenated analogs of deoxycytidine as selective inhibitors of the replication of herpes simplex viruses in cell culture and related studies of intracranial herpes simplex virus infections in mice. Ann N Y Acad Sci. 1975 Aug 8;255:359–365. doi: 10.1111/j.1749-6632.1975.tb29243.x. [DOI] [PubMed] [Google Scholar]
  4. KAUFMAN H. E. Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine. Proc Soc Exp Biol Med. 1962 Feb;109:251–252. doi: 10.3181/00379727-109-27169. [DOI] [PubMed] [Google Scholar]
  5. KAUFMAN H. E., HEIDELBERGER C. THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS. Science. 1964 Aug 7;145(3632):585–586. doi: 10.1126/science.145.3632.585. [DOI] [PubMed] [Google Scholar]
  6. Pavan-Langston D., Dohlman C. H. A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. Am J Ophthalmol. 1972 Jul;74(1):81–88. doi: 10.1016/0002-9394(72)91130-0. [DOI] [PubMed] [Google Scholar]
  7. Puliafito C. A., Robinson N. L., Albert D. M., Pavan-Langston D., Lin T. S., Ward D. C., Prusoff W. H. Therapy of experimental herpes simplex keratitis in rabbits with 5-lodo-5'-amino-2',5'-dideoxyuridine (39882). Proc Soc Exp Biol Med. 1977 Oct;156(1):92–96. doi: 10.3181/00379727-156-39882. [DOI] [PubMed] [Google Scholar]
  8. Schaeffer H. J., Beauchamp L., de Miranda P., Elion G. B., Bauer D. J., Collins P. 9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group. Nature. 1978 Apr 13;272(5654):583–585. doi: 10.1038/272583a0. [DOI] [PubMed] [Google Scholar]
  9. Whitley R. J., Soong S. J., Dolin R., Galasso G. J., Ch'ien L. T., Alford C. A. Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study. N Engl J Med. 1977 Aug 11;297(6):289–294. doi: 10.1056/NEJM197708112970601. [DOI] [PubMed] [Google Scholar]

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