Abstract
The minimum inhibitory concentrations of a halogenated quinoline, 3-amino-7-chloro-3,4-dihydro-1-hydroxycarbostyril (CBS), against nine clinical strains of Cryptococcus neoformans were determined by in vitro testing. The CBS was fungistatic at a minimum concentration of 0.2 μg/ml at 48 h for several strains. In vivo toxicity studies were carried out in mice. Mice were also infected with C. neoformans strain Price and injected with various concentrations of CBS. Mean life expectancy of treated groups of animals was increased over infected untreated controls.
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Selected References
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- Davis A. L., Chambers W. H., Kelley D. H., Fell D. A., Haynes J. R., Hulme K. L., Gage L. D., McCord T. J. Synthesis and antibacterial activities of some chloro analogs of 3 amino-3,4-dihydro-1-hydroxycarbostyril. J Med Chem. 1975 Jul;18(7):752–755. doi: 10.1021/jm00241a022. [DOI] [PubMed] [Google Scholar]
- Davis A. L., Hulme K. L., Wilson G. T., McCord T. J. In vitro antimicrobial activity of some cyclic hydroxamic acids and related lactams. Antimicrob Agents Chemother. 1978 Mar;13(3):542–544. doi: 10.1128/aac.13.3.542. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kobayashi G. S., Medoff G. Antifungal agents: recent developments. Annu Rev Microbiol. 1977;31:291–308. doi: 10.1146/annurev.mi.31.100177.001451. [DOI] [PubMed] [Google Scholar]
- Miller R. P., Bates J. H. Amphotericin B toxicity. A follow-up report of 53 patients. Ann Intern Med. 1969 Dec;71(6):1089–1095. doi: 10.7326/0003-4819-71-6-1089. [DOI] [PubMed] [Google Scholar]
- Newberry W. M. Drug treatment of the systemic mycoses. Semin Drug Treat. 1972 Winter;2(3):313–329. [PubMed] [Google Scholar]