Abstract
The anaerobic minimum inhibitory concentration of six aminoglycosides (amikacin, gentamicin, kanamycin, netilmicin, sisomicin, and tobramycin) averaged over 10-fold greater than the aerobic minimum inhibitory concentration for 50 clinical isolates of Staphylococcus aureus. Cultures from osteomyelitis and blood generally showed a somewhat greater increase in minimum inhibitory concentration due to anaerobiosis than did cultures from abscesses and wounds, and amikacin activity was most affected by anaerobiosis.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bingham E. L., Hart G. B. Hyperbaric oxygen treatment of refractory osteomyelitis. Postgrad Med. 1977 Jun;61(6):70–76. doi: 10.1080/00325481.1977.11712216. [DOI] [PubMed] [Google Scholar]
- Bryan L. E., Van Den Elzen H. M. Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob Agents Chemother. 1977 Aug;12(2):163–177. doi: 10.1128/aac.12.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans J. B., Harrell L. J. Agar shake tube technique for simultaneous determination of aerobic and anaerobic susceptibility to antibiotics. Antimicrob Agents Chemother. 1977 Oct;12(4):534–536. doi: 10.1128/aac.12.4.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- George R. H., Healing D. E. Letter: Gentamicin resistance. Lancet. 1976 Jan 31;1(7953):258–258. doi: 10.1016/s0140-6736(76)91391-x. [DOI] [PubMed] [Google Scholar]
- Harrell L. J., Evans J. B. Effect of anaerobiosis on antimicrobial susceptibility of staphylococci. Antimicrob Agents Chemother. 1977 Jun;11(6):1077–1078. doi: 10.1128/aac.11.6.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hays R. C., Mandell G. L. PO2, pH, and redox potential of experimental abscesses. Proc Soc Exp Biol Med. 1974 Oct;147(1):29–30. doi: 10.3181/00379727-147-38275. [DOI] [PubMed] [Google Scholar]
- KOGUT M., LIGHTBROWN J. W., ISAACSON P. STREPTOMYCIN ACTION AND ANAEROBIOSIS. J Gen Microbiol. 1965 May;39:155–164. doi: 10.1099/00221287-39-2-155. [DOI] [PubMed] [Google Scholar]
- Lacey R. W. Dwarf-colony variants of Staphylococcus aureus resistant to aminoglucoside antibiotics and to a fatty acid. J Med Microbiol. 1969 Aug;2(3):187–197. doi: 10.1099/00222615-2-3-187. [DOI] [PubMed] [Google Scholar]
- Musher D. M., Baughn R. E., Templeton G. B., Minuth J. N. Emergence of variant forms of Staphylococcus aureus after exposure to gentamicin and infectivity of the variants in experimental animals. J Infect Dis. 1977 Sep;136(3):360–369. doi: 10.1093/infdis/136.3.360. [DOI] [PubMed] [Google Scholar]
- Norden C. W. Experimental osteomyelitis. V. Therapeutic trials with oxacillin and sisomicin alone and in combination. J Infect Dis. 1978 Feb;137(2):155–160. doi: 10.1093/infdis/137.2.155. [DOI] [PubMed] [Google Scholar]
- Reynolds A. V., Hamilton-Miller J. M., Brumfitt W. Diminished effect of gentamicin under anaerobic or hypercapnic conditions. Lancet. 1976 Feb 28;1(7957):447–449. doi: 10.1016/s0140-6736(76)91474-4. [DOI] [PubMed] [Google Scholar]
- Rosenblatt J. E., Schoenknecht F. Effect of several components of anaerobic incubation on antibiotic susceptibility test results. Antimicrob Agents Chemother. 1972 May;1(5):433–440. doi: 10.1128/aac.1.5.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Verklin R. M., Jr, Mandell G. L. Alteration of effectiveness of antibiotics by anaerobiosis. J Lab Clin Med. 1977 Jan;89(1):65–71. [PubMed] [Google Scholar]
- Vogel L., Nathan C., Sweeney H. M., Kabins S. A., Cohen S. Infections due to gentamicin-resistant Staphylococcus aureus strain in a nursery for neonatal infants. Antimicrob Agents Chemother. 1978 Mar;13(3):466–472. doi: 10.1128/aac.13.3.466. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILLIAMSON G. M., WHITE F. Dihydrostreptomycin and anaerobiosis: comparison with other antibiotics and its selectivity with regard to obligate anaerobes. J Gen Microbiol. 1956 Jul;14(3):637–642. doi: 10.1099/00221287-14-3-637. [DOI] [PubMed] [Google Scholar]
- Wilson S. G., Sanders C. C. Selection and characterization of strains of Staphylococcus aureus displaying unusual resistance to aminoglycosides. Antimicrob Agents Chemother. 1976 Sep;10(3):519–525. doi: 10.1128/aac.10.3.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
