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. 1979 Jan;15(1):28–33. doi: 10.1128/aac.15.1.28

Pharmacokinetics of Amoxicillin: Dosage Nomogram for Patients with Impaired Renal Function

Guy Humbert 1, Daniel A Spyker 2, J P Fillastre 3, Annie Leroy 1
PMCID: PMC352595  PMID: 426503

Abstract

Amoxicillin pharmacokinetics after intravenous administration were studied in patients with normal renal function, with impaired renal function, and during hemodialysis. The average urinary recovery was 68% in patients with normal renal function. Serum half-life was highly correlated (r = 0.967) with creatinine clearance corrected for body weight. Expected half-life was 71 min for a corrected creatinine clearance of 100 ml/min per 70 kg and 16 h in the anephric patient. Average amoxicillin half-life on hemodialysis was 3.6 h. We present a dosage nomogram for making appropriate adjustments to loading dose based on patient weight and maintenance dose based on corrected creatinine clearance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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