Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Jan;15(1):134–136. doi: 10.1128/aac.15.1.134

Enveloped Virus Inactivation by Fatty Acid Derivatives

J A Sands 1, P Landin 1, D Auperin 1, A Reinhardt 1
PMCID: PMC352613  PMID: 218498

Abstract

The enveloped bacteriophage φ6 has been shown to be a valuable model system for the preliminary screening of compounds that might be expected to inactivate herpes simplex virus and other enveloped mammalian viruses. A variety of fatty acid derivatives that form fluid micelles in aqueous media have been found to be potent inactivators of φ6. The chemical nature of the polar head group, the length of the alkyl chain(s), and the extent and geometry of unsaturation are all important parameters in determining the antiviral effectiveness of this class of compounds.

Full text

PDF
134

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bamford D. H., Palva E. T., Lounatmaa K. Ultrastructure and life cycle of the lipid-containing bacteriophage phi 6. J Gen Virol. 1976 Aug;32(2):249–259. doi: 10.1099/0022-1317-32-2-249. [DOI] [PubMed] [Google Scholar]
  2. Jordan G. W., Seet E. C. Antiviral effects of amphotericin B methyl ester. Antimicrob Agents Chemother. 1978 Feb;13(2):199–204. doi: 10.1128/aac.13.2.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Sands J. A. Inactivation and inhibition of replication of the enveloped bacteriophage phi6 by fatty acids. Antimicrob Agents Chemother. 1977 Oct;12(4):523–528. doi: 10.1128/aac.12.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Sands J., Auperin D., Snipes W. Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols. Antimicrob Agents Chemother. 1979 Jan;15(1):67–73. doi: 10.1128/aac.15.1.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Snipes W., Person S., Keith A., Cupp J. Butylated hydroxytoluene inactivated lipid-containing viruses. Science. 1975 Apr 4;188(4183):64–66. doi: 10.1126/science.163494. [DOI] [PubMed] [Google Scholar]
  6. Snipes W., Person S., Keller G., Taylor W., Keith A. Inactivation of lipid-containing viruses by long-chain alcohols. Antimicrob Agents Chemother. 1977 Jan;11(1):98–104. doi: 10.1128/aac.11.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Vidaver A. K., Koski R. K., Van Etten J. L. Bacteriophage phi6: a Lipid-Containing Virus of Pseudomonas phaseolicola. J Virol. 1973 May;11(5):799–805. doi: 10.1128/jvi.11.5.799-805.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES