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. 1979 Feb;15(2):152–156. doi: 10.1128/aac.15.2.152

Investigations of the Occurrence of Gentamicin-Resistant Staphylococcus aureus

Frederick J Buckwold 1,2,4, William L Albritton 1,3,4, Allan R Ronald 1,2,4, Joy Lertzman 5, Ruby Henriksen 5
PMCID: PMC352624  PMID: 371541

Abstract

During the 19-month period from June 1976 to December 1977, 90 patients became colonized or infected with gentamicin-resistant Staphylococcus aureus (GRS). Of 63 adults, 56 had hospital-acquired GRS, whereas only 9 of 27 children had hospital-acquired GRS (P < 0.001). The other 7 adults and 18 children had GRS present on admission. More than half of those who acquired GRS in the hospital had received prior aminoglycoside therapy. Attack rates were higher in adults than in children and significantly higher on the plastic surgery service than on any other adult service. Phage typing revealed a single-strain outbreak on the plastic surgery ward involving 11 patients, whereas other isolates were of several phage types. Community-acquired GRS occurred more frequently in rural native communities (P < 0.02) and may be related to the use of topical gentamicin. Of 17 native children, 10 were from the same area but there was no common phage type. Agar dilution minimal inhibitory concentration (MIC) testing confirmed that all isolates were gentamicin resistant (MIC ≥ 8 μg/ml) and almost all were tobramycin resistant (MIC ≥ 8 μg/ml). Although the MIC distribution between gentamicin disk-susceptible and -resistant strains was significantly different, MIC's for 90% of gentamicin disk-resistant strains were ≤8 μg of amikacin per ml, and MIC's for 92% of the strains were ≤4 μg of netilmicin per ml.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Bint A. J., George R. H., Healing D. E., Wise R., Davies M. An outbreak of infection caused by a gentamicin-resistant Staphylococcus aureus. J Clin Pathol. 1977 Feb;30(2):165–167. doi: 10.1136/jcp.30.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burke P. J., Braine H. G., Rathbun H. K., Owens A. H., Jr The clinical significance and management of fever in acute myelocytic leukemia. Johns Hopkins Med J. 1976 Jul;139(1):1–12. [PubMed] [Google Scholar]
  4. Dowding J. E. Mechanisms of gentamicin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 1977 Jan;11(1):47–50. doi: 10.1128/aac.11.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gaman W., Cates C., Snelling C. F., Lank B., Ronald A. R. Emergence of gentamicin- and carbenicillin-resistant Pseudomonas aeruginosa in a hospital environment. Antimicrob Agents Chemother. 1976 Mar;9(3):474–480. doi: 10.1128/aac.9.3.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gurwith M., Brunton J. L., Lank B., Ronald A. R., Harding G. K., McCullough D. W. Granulocytopenia in hospitalized patients. II. A prospective comparison of two antibiotic regimens in the empiric therapy of febrile patients. Am J Med. 1978 Jan;64(1):127–132. doi: 10.1016/0002-9343(78)90188-2. [DOI] [PubMed] [Google Scholar]
  7. Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Perceval A., McLean A. J., Wellington C. V. Emergence of gentamicin resistance in Staphylococcus aureus. Med J Aust. 1976 Jul 10;2(2):74–74. doi: 10.5694/j.1326-5377.1976.tb117630.x. [DOI] [PubMed] [Google Scholar]
  9. Porthouse A., Brown D. F., Smith R. G., Rogers T. Gentamicin resistance in Staphylococcus aureus. Lancet. 1976 Jan 3;1(7949):20–21. doi: 10.1016/s0140-6736(76)92912-3. [DOI] [PubMed] [Google Scholar]
  10. Richards F., McCall C., Cox C. Gentamicin treatment of staphylococcal infections. JAMA. 1971 Feb 22;215(8):1297–1300. [PubMed] [Google Scholar]
  11. Shannon K. P., Phillips I. Letter: Gentamicin-resistant staphylococcus aureus. Lancet. 1976 Sep 11;2(7985):580–581. doi: 10.1016/s0140-6736(76)91835-3. [DOI] [PubMed] [Google Scholar]
  12. Shanson D. C., Kensit J. C., Duke R. Outbreak of hospital infection with a strain of Staphylococcus aureus resistant to gentamicin and methicillin. Lancet. 1976 Dec 18;2(7999):1347–1348. doi: 10.1016/s0140-6736(76)91986-3. [DOI] [PubMed] [Google Scholar]
  13. Soussy C. J., Bouanchaud D. H., Fouace J., Dublanchet A., Duval J. A gentamycin resistance plasmid in Staphylococcus aureus. Ann Microbiol (Paris) 1975 Jul-Aug;126B(1):91–94. [PubMed] [Google Scholar]
  14. Soussy C. J., Dublanchet A., Cormier M., Bismuth R., Mizon F., Chardon H., Duval J., Fabiani G. Nouvelles résistances plasmidiques de Staphylococcus aureus aux aminosides (gentamicine, tobramycine, amikacine) Nouv Presse Med. 1976 Nov;5(39):2599–2602. [PubMed] [Google Scholar]
  15. Speller D. C., Raghunath D., Stephens M., Viant A. C., Reeves D. S., Wilkinson P. J., Broughall J. M., Holt H. A. Epidemic infection by a gentamicin-resistant Staphylococcus aureus in three hospitals. Lancet. 1976 Feb 28;1(7957):464–466. doi: 10.1016/s0140-6736(76)91485-9. [DOI] [PubMed] [Google Scholar]
  16. Warren R. E., Roberts S. O. Letter: Gentamicin-resistant Staphylococci. Lancet. 1976 Mar 6;1(7958):543–544. doi: 10.1016/s0140-6736(76)90336-6. [DOI] [PubMed] [Google Scholar]
  17. Wood D. O., Carter M. J., Best G. K. Plasmid-mediated resistance to gentamicin in Staphylococcus aureus. Antimicrob Agents Chemother. 1977 Oct;12(4):513–517. doi: 10.1128/aac.12.4.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wyatt T. D., Ferguson W. P., Wilson T. S., McCormick E. Gentamicin resistant Staphylococcus aureus associated with the use of topical gentamicin. J Antimicrob Chemother. 1977 May;3(3):213–217. doi: 10.1093/jac/3.3.213. [DOI] [PubMed] [Google Scholar]

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