Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Mar;15(3):368–371. doi: 10.1128/aac.15.3.368

Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties

Thomas W Miller 1, Louis Chaiet 1, Douglas J Cole 1, Lucille J Cole 1, James E Flor 1, Robert T Goegelman 1, Vincent P Gullo 1, Henry Joshua 1, August J Kempf 1, Wilson R Krellwitz 1, Richard L Monaghan 1, Robert E Ormond 1, Kenneth E Wilson 1, George Albers-Schönberg 1, Irving Putter 1
PMCID: PMC352667  PMID: 464562

Abstract

The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were separated from the complex. Solvent extraction, solvent partition, and adsorption methods were used to isolate and purify the complex; novel partition chromatography systems using Sephadex LH-20 were used to separate the components. A reverse-phase high-pressure liquid chromatography assay for the quantitative determination of all components was used extensively to monitor the purification methods.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burg R. W., Miller B. M., Baker E. E., Birnbaum J., Currie S. A., Hartman R., Kong Y. L., Monaghan R. L., Olson G., Putter I. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob Agents Chemother. 1979 Mar;15(3):361–367. doi: 10.1128/aac.15.3.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Egerton J. R., Ostlind D. A., Blair L. S., Eary C. H., Suhayda D., Cifelli S., Riek R. F., Campbell W. C. Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component. Antimicrob Agents Chemother. 1979 Mar;15(3):372–378. doi: 10.1128/aac.15.3.372. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES