Socioeconomic position predicts long-term depression trajectory: a 13-year follow-up of the GAZEL cohort study

Abstract

Individuals with low socioeconomic position have high rates of depression; however, it is not clear whether this reflects higher incidence or longer persistence of disorder. Past research focused on high-risk samples, and risk factors of long-term depression in the population are less well known. Our aim was to test the hypothesis that socioeconomic position predicts depression trajectory over 13 years of follow-up in a community sample. We studied 12 650 individuals participating in the French GAZEL study. Depression was assessed by the Center for Epidemiological Studies-Depression scale in 1996, 1999, 2002, 2005 and 2008. These five assessments served to estimate longitudinal depression trajectories (no depression, decreasing depression, intermediate/increasing depression, persistent depression). Socioeconomic position was measured by occupational grade. Covariates included year of birth, marital status, tobacco smoking, alcohol consumption, body mass index, negative life events and preexisting psychological and non-psychological health problems. Data were analyzed using multinomial regression, separately in men and women. Overall, participants in intermediate and low occupational grades were significantly more likely than those in high grades to have an unfavorable depression trajectory and to experience persistent depression (age-adjusted ORs: respectively 1.40, 95% confidence interval (CI) 1.16–1.70 and 2.65, 95% CI 2.04–3.45 in men, 2.48, 95% CI 1.36–4.54 and 4.53, 95% CI 2.38–8.63 in women). In multivariate models, the socioeconomic gradient in long-term depression decreased by 21–59% in men and women. Long-term depression trajectories appear to follow a socioeconomic gradient; therefore, efforts aiming to reduce the burden of depression should address the needs of the whole population rather than exclusively focus on high-risk groups.

Introduction

Each year, 3–7% of individuals living in industrialized countries suffer from depression; 10–15% are affected over the course of their lifetime.^{1, 2} Among people who have depression at a particular point in time, an estimated 35–50% will experience symptoms that are recurrent or persistent^{3, 4} and another 20% may have residual symptoms that impair daily activities and increase the long-term risk of physical health, social and economic difficulties.⁵ Identifying factors that predict depression trajectories over time is important from both a clinical and a public health perspective.

Previous research suggests that depression is especially likely to occur among individuals who have low socioeconomic position, as measured by educational level, occupational grade or income.⁶ However, it is not clear whether socioeconomic position predicts depression trajectories over time. First, with few exceptions,^{7, 8, 9, 10, 11} previous studies reporting socioeconomic inequalities with regard to depression persistence have been based on high-risk or clinical samples,^{12, 13, 14, 15} which may not be sufficiently varied to contrast groups with different levels of resources.^{6, 16} Second, prior investigations based on community samples were characterized by limited follow-up (up to 3 years),^{7, 8, 10} high attrition (13% per year over a 7-year follow-up)⁹ or followed individuals who were depressed at baseline.¹¹ Growing evidence suggests that in the population, most health outcomes follow a socioeconomic gradient,¹⁷ and there is need for additional data on determinants of depression trajectories in broad samples. Third, although depression rates and the role of socioeconomic factors may vary with sex,^{18, 19} until now, prior studies did not consider women and men separately.

Using data from the French GAZEL cohort study, we examined the association between socioeconomic position, as assessed by occupational grade, and depression trajectories over 13 years of follow-up. Specifically, we studied the association between socioeconomic characteristics and depression trajectories net of the effect of factors that may be simultaneously associated with socioeconomic position and depression trajectory such as age, sex, marital status, negative life events, tobacco and alcohol use,²⁰ body weight index,²¹ and preexisting psychological and physical health problems.^{20, 22}

Materials and methods

Study population

The GAZEL cohort is an ongoing epidemiological study set up in 1989 among employees of France's national gas and electricity company (n=20 624).²³ The study uses an annual questionnaire to collect data on health, lifestyle, individual, familial, social and occupational factors. Additional data are available through various sources, including EDF-GDF administrative records. Since inception of the study in 1989, <1% of participants left the company (n=99) or requested to leave the study (n=264), 6% died (n=1314) and ∼75% completed the yearly study questionnaire. Attrition during follow-up was shown to be related to concomitant health problems, as well as, to a lesser extent, socioeconomic position.²⁴ However, as all participants are sent the yearly study questionnaire (up to date coordinates of all study participants recruited at baseline are available through EDF-GDF administrative records), even those who are not able to participate in a particular year are able to come back into the study during a subsequent wave of data collection. The GAZEL study received approval from the national commission overseeing the ethical data collection in France (Commission Nationale Informatique et Liberté) and from the INSERM's Institutional Review Board.

Measures

Depressive symptoms were measured in 1996, 1999, 2002, 2005 and 2008 using the Center for Epidemiological Studies-Depression (CES-D) scale.²⁵ This scale includes 20 items, which describe symptoms and behaviors characteristic of depressive disorder. On the basis of a previous validation against clinical diagnosis conducted in France, we used cutoff scores of ⩾17 in men and ⩾23 in women to determine the presence of clinically significant depressive symptoms, referred to as depression from here on.^{26, 27}

Occupational grade at the beginning of follow-up and employment status (retired vs actively working) were obtained from EDF-GDF administrative records. Occupational grade was coded according to France's national job classification:²⁸ low (manual worker/clerk), intermediate (administrative associate professional/technician) or high (manager). Study participants were middle-aged and worked for a large national company, therefore, occupational grade was stable throughout the follow-up period.

Covariates

All covariates were measured up to the baseline measure of depression, as our aim was to identify predictors of depression trajectories (i.e., covariates were not dependent on time). Participants' sociodemographic characteristics and health behaviors were assessed in the 1996 GAZEL cohort survey: year of birth (1939–1943, 1944–1949, 1950–1954), marital status (divorced/separated/widowed or married/living with a partner), tobacco smoking status (non-smoker or smoker), alcohol consumption (none, moderate: women: 1–20 units of alcohol per week, men: 1–27 units of alcohol per week, or heavy: women: 21 or more units of alcohol per week, men: 28 or more units of alcohol per week), body mass index (<25 kg m⁻², 25–29 kg m⁻², ⩾30 kg m⁻²). Negative life events (divorce/marital breakup, spouse's death, spouse's job loss, hospitalization, spouse's hospitalization) were measured yearly between 1990 and 1996. Preexisting health problems were measured yearly between 1989 and 1996 via a self-completed checklist: psychological problems (depression, treated depression or treated sleep problems²⁹), chronic physical illness (respiratory disorders, cardiovascular disorder, arthritis and diabetes) and cancer.

Statistical analysis

To test the association between occupational grade and depression trajectory, we restricted the study sample to GAZEL study participants with complete data on at least three out of the five possible depression measures (n=12 789). Participants excluded from the analysis were more likely to be female, to work in low occupational grades and to be depressed in 1996. Depression trajectories were determined using a semi-parametric mixture model³⁰ implemented with the PROC TRAJ procedure available in SAS (Cary, NC, USA). For each depression group, the model defines the shape of the trajectory and the proportion of participants in each group. In order to define the optimal number of trajectories, several models were fitted, from a 1-group trajectory model to a 6-group trajectory model. Using the Bayesian Information Criterion,³¹ a fit index, in which lower values indicate a more parsimonious model, we determined that a 4-group solution was the best fit for our data.

After defining the depression trajectories, we estimated the association between socioeconomic position and the probability of belonging to each of the depression groups using multinomial logistic regression models in which the ‘no depression' trajectory group served as the reference category.

Our analytical strategy was as follows: first, we tested associations between occupational grade and depression trajectories adjusting for year of birth; next, we successively controlled for each block of covariates (1. marital status, 2. negative life events, 3. health behaviors, 4. preexisting health problems). Finally, we tested the association between occupational grade and depression trajectory adjusting for all covariates. To calculate the contribution of each block of explanatory variables to the occupational gradient in depression we repeated the analysis testing the relationship between a single 3-level occupational grade variable and compared adjusted vs non-adjusted odds ratios (ORs) with the following formula: (ORadjusted for year of birth−ORadjusted for year of birth+variable of interest/ORadjusted for year of birth−1) × 100. All analyses were conducted separately in men and women, using the SAS statistical software package.

Results

The four depression trajectory groups identified in our study were as follows: men: no depression (72.0%, n=6787), increasing depression (4.2%, n=385), decreasing depression (17.8%, n=1683), persistent depression (6.0%, n=569); women: no depression (58.1%, 1873), decreasing depression (14.0%, n=452), intermittent depression (21.8%, n=702), persistent depression (6.1%, n=199) (Figures 1 and 2).

Figure 1.

Depression trajectories among men of the GAZEL cohort (1996–2008).

Figure 2.

Depression trajectories among women of the GAZEL cohort (1996–2008).

In additional analyses we verified that participants in the ‘no depression' group were depressed an average of 0.13 times during the follow-up (s.d.=0.33), as compared with 1.79 times in participants in the ‘decreasing depression' group (s.d.=0.61), 1.09 times in participants in the ‘increasing depression' group (s.d.=0.28), 2.48 times in participants in the ‘intermittent depression' group (s.d.=0.93) and 4.26 times in participants in the ‘persistent depression' group (s.d.=0.84).

Tables 1 and 2 show characteristics of male and female study participants in relation to depression trajectory. As expected, we found an association between occupational grade and depression trajectory group (P<0.0001). In addition, the pattern of depression over time was significantly associated with participants' year of birth, marital status, divorce or partner separation, hospitalization, spouse's hospitalization, tobacco smoking (men only), alcohol use, body mass index (men only), past psychological problems, chronic physical illness and cancer (women only).

Table 1. Characteristics of men of the GAZEL cohort in relation to depression trajectories (1996–2008), n=9424 (%, P-value).

	No depression (n=6787)	Increasing depression (n=385)	Decreasing depression (n=1683)	Persistent depression (n=569)	P-value
Sociodemographic characteristics
Occupational grade:
High	42.3	39.2	36.9	31.6
Intermediate	49.0	53.8	52.1	51.3
Low	8.6	7.0	11.0	17.1	<0.0001
Year of birth:
1939–1943	43.2	50.1	39.5	41.5
1944–1949	56.8	49.9	60.5	58.5	0.0007
Marital status:
Married/living with partner	93.6	93.8	89.8	84.0
Single/widowed/divorced	6.4	6.2	10.2	16.0	<0.0001
Negative life events
Divorce/separation	4.1	3.1	6.1	9.3	<0.0001
Spouse's death	1.4	1.3	2.0	1.9	0.26
Spouse's unemployment	5.8	7.5	7.4	7.0	0.06
Hospitalization	22.8	26.8	29.1	33.0	<0.0001
Spouse's hospitalization	19.4	22.6	22.2	20.6	0.041
Health behaviors
Tobacco smoking:
Non-smoker	82.7	83.1	80.4	77.2
Current smoker	17.3	16.9	19.6	22.8	0.0021
Alcohol use:
Moderate	77.6	78.4	75.4	74.2
High	14.7	14.8	15.9	14.1
None	7.7	6.8	8.8	11.8	0.018
BMI (kg m−2)
⩽25	41.0	42.9	38.1	39.4
>25–29	50.6	48.8	52.1	47.8
⩾30	8.4	8.3	9.8	12.8	0.0043
Preexisting health problems
Psychological problems	12.5	20.5	38.1	58.6	<0.0001
Chronic physical illnessa	51.6	61.0	62.8	69.4	<0.0001
Cancer	1.3	1.3	1.7	2.1	0.33

Abbreviation: BMI, body mass index.

^aChronic physical illnesses considered include: respiratory disorders, cardiovascular disorder, arthrosis and diabetes.

Table 2. Characteristics of women of the GAZEL cohort in relation to depression trajectories (1996–2008), n=3226 (%, P-value).

	No depression (n=1873)	Decreasing depression (n=452)	Intermittent depression (n=702)	Persistent depression (n=199)	P-value
Sociodemographic characteristics
Occupational grade:
High	15.5	11.3	9.8	6.0
Intermediate	68.5	69.9	69.0	65.8
Low	16.0	18.8	21.2	28.2	<0.0001
Year of birth:
1939–1943	28.7	23.0	19.4	28.1
1944–1949	35.8	40.7	36.0	33.7
1950–1954	35.5	36.3	44.6	39.2	<0.0001
Marital status:
Married/living with partner	79.4	73.5	74.1	64.3
Single/widowed/divorced	20.6	26.5	25.9	35.7	<0.0001
Negative life events
Divorce/separation	6.3	9.3	8.4	16.1	<0.0001
Spouse's death	2.2	3.3	2.0	3.0	0.42
Spouse's unemployment	7.3	7.7	9.7	5.0	0.094
Hospitalization	27.1	33.2	37.9	41.7	<0.0001
Spouse's hospitalization	13.4	12.8	17.7	15.6	0.033
Health behaviors
Tobacco smoking:
Non-smoker	87.3	85.0	84.8	83.4
Current smoker	12.7	15.0	15.2	16.6	0.17
Alcohol use:
Moderate	75.5	74.8	70.8	66.3
High	4.5	3.1	4.1	4.0
None	20.0	22.1	25.1	29.7	0.011
BMI (kg m−2)
⩽25	73.6	73.0	75.1	69.4
>25–29	20.2	21.9	17.9	20.6
⩾30	6.1	5.1	7.0	10.0	0.17
Preexisting health problems
Psychological problems	29.4	64.4	68.2	85.4	<0.0001
Chronic physical illnessa	52.8	64.4	63.7	80.4	<0.0001
Cancer	3.1	3.3	3.1	6.5	0.082

Abbreviation: BMI, body mass index.

^aChronic physical illnesses include: respiratory disorders, cardiovascular disorder, arthrosis and diabetes.

In men (Table 3), multinomial regression models adjusted for year of birth revealed no association between occupational grade and increasing depression symptoms over time; however, the probability of decreasing or persistent levels of depression followed an occupational gradient. Compared with participants with high occupational grade and no depression during follow-up, in participants with intermediate occupational grade, the odds of belonging to the group with decreasing levels of depression or to the group with persistent depression were, respectively, 1.22 (95% confidence interval (CI) 1.09–1.36) and 1.40 (95% CI 1.16–1.70) times higher. In participants with low occupational grade, the corresponding ORs were 1.45 (95% CI 1.21–1.75) for decreasing levels of depression and 2.65 (95% CI 2.04–3.45) for persistent depression. The likelihood of persistent depression associated with occupational grade was significantly higher than the likelihood of decreasing or increasing depression (P-values, respectively: <0.0001 and 0.0003). These occupational gradients somewhat decreased after adjusting for marital status (decreasing depression: 3%, persistent depression: 3%), negative life events (decreasing depression: 3%, persistent depression: 1%), health behaviors (decreasing depression: 6%, persistent depression: 5%) and preexisting health problems (decreasing depression: 14%, persistent depression: 9%). In fully adjusted models, the ORs associated with occupational grade decreased by 21% with regard to decreasing depression and by 16% with regard to persistent depression, but remained elevated and statistically significant.

Table 3. Socioeconomic position and depression trajectory (1996–2008); multinomial logistic regression analyses among men of the GAZEL cohort (n=9424).

	Increasing vs no depression OR1 (95% CI)	Decreasing vs no depression OR2 (95% CI)	Persistent vs no depression OR3 (95% CI)	P-value 1 OR1, OR2, OR3 ≠ 1
Adjusted for year of birth
Occupational grade:
High	1	1	1	<0.0001
Intermediate	1.20 (0.97–1.49)	1.22 (1.09–1.36)	1.40 (1.16–1.70)
Low	0.90 (0.59–1.37)	1.45 (1.21–1.75)	2.65 (2.04–3.45)
Adjusted for year of birth and marital status
Occupational grade:
High	1	1	1
Intermediate	1.20 (0.97–1.49)	1.21 (1.08–1.35)	1.38 (1.13–1.67)
Low	0.90 (0.59–1.37)	1.44 (1.19–1.74)	2.59 (1.99–3.37)	<0.0001
Adjusted for year of birth and negative life eventsa
Occupational grade:
High	1	1	1
Intermediate	1.20 (0.96–1.49)	1.21 (1.08–1.35)	1.39 (1.14–1.68)
Low	0.89 (0.59–1.36)	1.44 (1.19–1.74)	2.63 (2.02–3.42)	<0.0001
Adjusted for year of birth and health behaviorsb
Occupational grade:
High	1	1	1
Intermediate	1.21 (0.98–1.50)	1.20 (1.07–1.35)	1.37 (1.13–1.67)
Low	0.91 (0.60–1.39)	1.42 (1.18–1.72)	2.54 (1.95–3.30)	<0.0001
Adjusted for year of birth and preexisting health problemsc
Occupational grade:
High	1	1	1
Intermediate	1.18 (0.95–1.46)	1.18 (1.05–1.33)	1.35 (1.10–1.65)
Low	0.85 (0.56–1.30)	1.37 (1.13–1.66)	2.42 (1.83–3.20)	<0.0001
Full modeld
Occupational grade:
High	1	1	1
Intermediate	1.18 (0.95–1.47)	1.17 (1.04–1.32)	1.30 (1.06–1.59)
Low	0.86 (0.56–1.31)	1.34 (1.10–1.63)	2.28 (1.72–3.02)	<0.0001

Abbreviations: CI, confidence interval; OR, odds ratio.

^aAdjusted for divorce/marital breakup, spouse's job loss, hospitalization and spouse's hospitalization.

^bAdjusted for tobacco smoking, alcohol use and body mass index.

^cAdjusted for past psychological problems, chronic physical illness (respiratory disorders, cardiovascular disorder, arthrosis and diabetes) and cancer.

^dAdjusted for year of birth, marital status, divorce/marital breakup, spouse's job loss, hospitalization, spouse's hospitalization, tobacco smoking, alcohol use, body mass index, past psychological problems, chronic physical illness (respiratory disorders, cardiovascular disorder, arthrosis and diabetes) and cancer.

Similarly, in women (Table 4) we observed an occupational gradient in the probability of decreasing, intermittent or persistent levels of depression: compared with participants with high occupational grade who were not depressed during follow-up, participants with intermediate occupational grade had odds of decreasing levels of depression, intermittent depression or persistent depression, respectively, 1.39 (95% CI 1.00–1.91), 1.59 (95% CI 1.20–2.11) and 2.48 (95% CI 1.36–4.54) times higher. In participants with low occupational grade, the corresponding ORs were 1.61 (95% CI 1.10–2.36) for decreasing depression, 2.09 (95% CI 1.51–2.91) for intermittent depression and 4.53 (95% CI 2.38–8.63) for persistent depression. The likelihood of persistent depression associated with occupational grade was significantly higher than the likelihood of decreasing or intermittent depression (P-values, respectively: 0.002 and 0.02). These occupational gradients somewhat decreased after adjusting for negative life events (decreasing depression: 6%, intermittent depression: 8%, persistent depression trajectory: 9%), health behaviors (decreasing depression: 2%, intermittent depression: 2%, persistent depression trajectory: 6%) and preexisting health problems (decreasing depression: 44%, intermittent depression: 33%, persistent depression trajectory: 26%). In fully adjusted models, the ORs associated with occupational grade decreased by 40% with regard to decreasing levels of depression, by 33% with regard to intermittent depression and by 59% with regard to persistent depression; they remained elevated and statistically significant for intermittent and persistent depression. The ORs associated with further analyses revealed that approximately half of the contribution of health characteristics to the occupational gradient in depression in women reflected the role of preexisting psychological problems.

Table 4. Socioeconomic position and depression trajectory (1996–2008): multinomial logistic regression analyses among women of the GAZEL cohort (n=3226).

	Decreasing vs no depression OR1 (95% CI)	Intermittent vs no depression OR2 (95% CI)	Persistent vs no depression OR3 (95% CI)	P-value 1 OR1, OR2, OR3 ≠ 1
Adjusted for year of birth
Occupational grade:
High	1	1	1
Intermediate	1.39 (1.00–1.91)	1.59 (1.20–2.11)	2.48 (1.36–4.54)
Low	1.61 (1.10–2.36)	2.09 (1.51–2.91)	4.53 (2.38–8.63)	<0.0001
Adjusted for year of birth and marital status
Occupational grade:
High	1	1	1
Intermediate	1.42 (1.03–1.97)	1.63 (1.23–2.17)	2.65 (1.45–4.87)
Low	1.65 (1.12–2.42)	2.14 (1.54–2.98)	4.80 (2.52–9.17)	<0.0001
Adjusted for year of birth and negative life eventsa
Occupational grade:
High	1	1	1
Intermediate	1.37 (0.99–1.89)	1.54 (1.16–2.06)	2.36 (1.29–4.33)
Low	1.57 (1.07–2.31)	1.99 (1.43–2.77)	4.12 (2.16–7.87)	<0.0001
Adjusted for year of birth and health behaviorsb
Occupational grade:
High	1	1	1
Intermediate	1.39 (1.00–1.92)	1.58 (1.19–2.10)	2.42 (1.32–4.44)
Low	1.60 (1.09–2.35)	2.06 (1.48–2.87)	4.57 (2.24–8.16)	<0.0001
Adjusted for year of birth and preexisting health problemsc
Occupational grade:
High	1	1	1
Intermediate	1.24 (0.88–1.72)	1.39 (1.03–1.87)	2.09 (1.12–3.90)
Low	1.33 (0.89–1.98)	1.69 (1.19–2.39)	3.34 (1.71–6.53)	0.0035
Full modeld
Occupational grade:
High	1	1	1
Intermediate	1.26 (0.90–1.77)	1.41 (1.04–1.91)	2.07 (1.10–3.88)
Low	1.36 (0.91–2.03)	1.69 (1.18–2.40)	3.13 (1.59–6.17)	0.0081

Abbreviations: CI, confidence interval; OR, odds ratio.

^aAdjusted for divorce/marital breakup, spouse's job loss, hospitalization and spouse's hospitalization.

^bAdjusted for tobacco smoking, alcohol use, and body mass index.

^cAdjusted for past psychological problems, chronic physical illness (respiratory disorders, cardiovascular disorder, arthrosis and diabetes) and cancer.

^dAdjusted for year of birth, marital status, divorce/marital breakup, spouse's job loss, hospitalization, spouse's hospitalization, tobacco smoking, alcohol use, body mass index, past psychological problems, chronic physical illness (respiratory disorders, cardiovascular disorder, arthrosis and diabetes) and cancer.

In secondary analyses, we found that participants who retired during follow-up had a lower probability of depression than those who remained employed (OR: 0.55), but adjustment for retirement status did not modify the association between occupational grade and depression trajectory (data available upon request). In addition, in order to test the possibility that the restriction of the study sample to participants with complete data induced bias, we repeated the analyses on the whole sample, using the default option for the management of missing data available in PROC TRAJ. We also conducted sensitivity analyses imputing missing data using the MICE procedure in STATA. The results obtained using these methods were not systematically different from those of the main analysis (not shown).

Discussion

In this study of 12 789 individuals followed for 13 years, we found evidence of four longitudinal depression trajectories: no depression, decreasing levels of depression, increasing (men) or intermittent (women) levels of depression and persistent depression. The probability of belonging to a group with depression over the course of follow-up was inversely related to occupational grade. This association was especially strong for persistent depression. Observed depression trajectories and possible explanations of the occupational gradient in depression varied in men and women. Adding to past research, which reported socioeconomic inequalities with regard to depression persistence in high-risk samples, our study suggests that socioeconomic position predicts the long-term occurrence of depressive disorder in a large community-based sample. Importantly, the risk of depression is not concentrated exclusively in the most disadvantaged groups of the population, but distributed across the whole socioeconomic range.

Limitations and strengths

Our results need to be interpreted in light of several limitations. First, the GAZEL cohort includes individuals who, at the time they were recruited into the cohort, held a stable job. Moreover, participants excluded from this analysis were more likely to belong to a low occupational grade and to be depressed. Past research based on GAZEL study data has shown associations between socioeconomic position and physical and mental health,^{32, 33, 34} implying that this sample is well suited to study social health inequalities and that the results will apply in other settings. Nevertheless, socioeconomic gradients with regard to long-term risk of depression in the general population are probably steeper than we report. Second, we did not account for several factors shown to predict the long-term risk of depressive symptomatology such as a family history of depression,³⁵ the age of onset of depressive disorder³⁶ and personality.³⁷ However, by accounting for preexisting psychological problems we most likely captured disorder variability associated with these predictors.⁴ Third, depression in our study was assessed using the CES-D scale, which is less specific than a clinician's diagnosis and bears the risk of false positives.³⁸ Still, it is a well-established screening instrument, shown to be reliable and valid across different cultural and sociodemographic settings. The cutoffs validated in France and used in this study (⩾17 in men and ⩾23 in women) are higher than those used in other populations (⩾16 in men and women), which probably decreases the likelihood of misclassification. Evidence of psychosocial impairment in individuals who have mild and moderate depression³⁹ suggests that measures of depressive symptomatology such as the CES-D can help identify individuals who require medical attention. Fourth, depression measures were obtained every 3 years, raising the possibility that we underestimated depression trajectories. Reassuringly, case undercounting appears rare (6% of participants self-reported psychological problems but were not identified as CES-D cases). Moreover, misclassification bias because of unaccounted cases is more likely to be a problem when studying the recurrence of depression at a specific point in time than when examining long-term trajectories of depression over multiple measurements, as is the case in the present study. Overall, the most likely consequence of case undercounting is the attenuation of the association between occupational grade and depression.

Our study also has several strengths: (1) the study sample was selected independently of mental health treatment status and is socioeconomically more varied than clinical samples; (2) the occurrence of depression was ascertained prospectively over a 13-year period, limiting information bias; (3) the analysis accounted for several factors associated with depression course measured longitudinally.

Socioeconomic gradient in depression course

Our main finding is that the long-term likelihood of depression appears to follow a socioeconomic gradient, that is individuals in the highest occupational groups are least likely to be depressed, followed by those in an intermediate position; individuals in lowest occupational groups are most likely to be depressed and to have depression that persists over time. Although the association between socioeconomic position and depression persistence has previously been reported,^{7, 8, 10, 11, 34} we are not aware of research quantifying socioeconomic inequalities in long-term depression patterns.

The association between socioeconomic position and depression may reflect two mechanisms: (1) health selection, whereby psychological symptoms cause individuals to drift down the social hierarchy and (2) social causation, whereby disadvantaged living conditions directly affect mental health.⁴⁰ Moreover, differential use of mental healthcare services may additionally contribute to worse depression outcomes in lower socioeconomic groups.⁴¹ This study, based on a sample of middle-aged, working, men and women was not designed to test the role of selection vs causation mechanisms. However, our results are consistent with both explanations. Although study participants held a stable job, which they were unlikely to lose in case of psychological problems, depression may have affected their chances of being promoted. Prior data from the GAZEL cohort show that social mobility over time is associated with cancer incidence and premature mortality, as well as risky health behaviors.^{32, 42, 43} By definition, study participants from the lowest occupational groups were not promoted during the course of their career, and it may be that in some cases this was due to their psychological problems. However, if health selection were the primary explanation, one would expect the probability of depression to be solely elevated among individuals in low occupational grades. The observation of a socioeconomic gradient suggests that position on the occupational ladder contributes to depression risk. Factors associated with depression in our study (absence of a partner, the experience of negative life events, tobacco smoking, high alcohol use, high body mass index, prior health problems) followed an occupational gradient and statistically explained up to 21% of the association between occupational grade and depression in men and up to 59% in women, implying that depression risk is partly shaped by socioeconomic circumstances.

Differences between men and women

In our study, men and women had different depression trajectories: women were less likely to have persistent depression than men (4.6% as compared with 6.3%), yet their overall levels of depression were higher (60.9% had no depression during follow-up as compared with 69.1% of men). It is important to highlight that the cutoffs used to define clinically significant depression were sex-specific and higher for women. Thus, sex differences are probably larger when the same criteria are applied to men and women. Although research has consistently reported that women have higher rates of depression at any given point in time, there has been some debate as to whether women also experience worse course of depression.^{18, 19, 44} Our data are consistent with the hypothesis that long-term patterns of depression are less favorable in women, possibly due to multiple affective, biological and cognitive mechanisms, which operate in interaction with exposure to stress.⁴⁵ We also found evidence of steeper socioeconomic gradients in women than in men, even in fully adjusted models. Among factors we controlled for, preexisting health problems had an especially important role in statistically explaining the socioeconomic gradient in depression in women, drawing attention to the interrelationship between mental and physical health. Overall, this study confirms that the prevalence as well as risk factors of depression differ in men and women, suggesting that investigations examining long-term patterns of depression should test for sex differences.

Conclusion

Adding to prior research, which showed that individuals who belong to disadvantaged socioeconomic groups have elevated rates of depression, our study suggests that the risk of depression follows a socioeconomic gradient, particularly when the disorder is chronic. In terms of theory, this finding argues in favor of a social causation explanation of persistent depression. In terms of practice, the main implication is that efforts aimed to reduce the burden of depression and decrease socioeconomic inequalities should address the mental health needs of the population.

The authors declare no conflict of interest.