Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Mar;15(3):452–454. doi: 10.1128/aac.15.3.452

In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

Patrick R Murray 1, Judy L Christman 1, Gerald Medoff 1
PMCID: PMC352682  PMID: 111612

Abstract

The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseria gonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of ≥0.5 μg/ml for penicillin) and three β-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 μg/ml and all inhibited by 0.25 μg/ml.

Full text

PDF
452

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bergström S., Norlander L., Norqvist A., Normark S. Contribution of a TEM-1-like beta-lactamase to penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1978 Apr;13(4):618–623. doi: 10.1128/aac.13.4.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Eickhoff T. C., Ehret J. M. In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. Antimicrob Agents Chemother. 1976 Jun;9(6):994–999. doi: 10.1128/aac.9.6.994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eykyn S., Jenkins C., King A., Phillips I. Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole. Antimicrob Agents Chemother. 1976 Apr;9(4):690–695. doi: 10.1128/aac.9.4.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fu K. P., Neu H. C. beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin. Antimicrob Agents Chemother. 1978 Sep;14(3):322–326. doi: 10.1128/aac.14.3.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Griffith R. S., Black H. R., Brier G. L., Wolny J. D. Cefamandole: in vitro and clinical pharmacokinetics. Antimicrob Agents Chemother. 1976 Nov;10(5):814–823. doi: 10.1128/aac.10.5.814. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  7. Karney W. W., Pedersen A. H., Nelson M., Adams H., Pfeifer R. T., Holmes K. K. Spectinomycin versus tetracycline for the treatment of gonorrhea. N Engl J Med. 1977 Apr 21;296(16):889–894. doi: 10.1056/NEJM197704212961601. [DOI] [PubMed] [Google Scholar]
  8. Kaufman R. E., Johnson R. E., Jaffe H. W., Thornsberry C., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: treatment results. N Engl J Med. 1976 Jan 1;294(1):1–4. doi: 10.1056/NEJM197601012940101. [DOI] [PubMed] [Google Scholar]
  9. Martin J. E., Jr, Lester A., Price E. V., Schmale J. D. Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969. J Infect Dis. 1970 Nov;122(5):459–461. doi: 10.1093/infdis/122.5.459. [DOI] [PubMed] [Google Scholar]
  10. Neu H. C., Fu K. P. Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of gram-positive and -negative activity. Antimicrob Agents Chemother. 1978 Apr;13(4):657–664. doi: 10.1128/aac.13.4.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. O'Callaghan C. H., Sykes R. B., Griffiths A., Thornton J. E. Cefuroxime, a new cephalosporin antibiotic: activity in vitro. Antimicrob Agents Chemother. 1976 Mar;9(3):511–519. doi: 10.1128/aac.9.3.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Powell J. T., Bond J. H. Multiple antibiotic resistance in clinical strains of Neisseria gonorrhoeae isolated in South Carolina. Antimicrob Agents Chemother. 1976 Oct;10(4):639–645. doi: 10.1128/aac.10.4.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rodriguez W., Saz A. K. Possible mechanism of decreased susceptibility of Neisseria gonorrhoeae to penicillin. Antimicrob Agents Chemother. 1975 Jun;7(6):788–792. doi: 10.1128/aac.7.6.788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sosna J. P., Murray P. R., Medoff G. Comparison of the in vitro activities of HR756 with cephalothin, cefoxitin, and cefamandole. Antimicrob Agents Chemother. 1978 Dec;14(6):876–879. doi: 10.1128/aac.14.6.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Thornsberry C., Jaffe H. W., Reynolds G. H., Zaidi A. A., Wiesner P. J. Patient variables associated with penicillin resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1978 Sep;14(3):327–330. doi: 10.1128/aac.14.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES