Abstract
The diffusibility of bacampicillin, ampicillin, cephalothin, and cephapirin into human interstitial fluid was investigated by using crossover studies. We compared bacampicillin with ampicillin and found that bacampicillin was better absorbed after oral administration. Blood, interstitial fluid, and urine levels were consistently higher in volunteers who received bacampicillin. We compared cephalothin with cephapirin and found that blood and interstitial fluid levels were comparable throughout the study.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Axelrod J., Meyers B. R., Hirschman S. Z. Cephapirin: pharmacology in normal human volunteers. J Clin Pharmacol New Drugs. 1972 Feb-Mar;12(2):84–88. doi: 10.1002/j.1552-4604.1972.tb00150.x. [DOI] [PubMed] [Google Scholar]
- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bergan T. Pharmacokinetic comparison of oral bacampicillin and parenteral ampicillin. Antimicrob Agents Chemother. 1978 Jun;13(6):971–974. doi: 10.1128/aac.13.6.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bodin N. O., Ekström B., Forsgren U., Jalar L. P., Magni L., Ramsay C. H., Sjöberg B. Bacampicillin: a new orally well-absorbed derivative of ampicillin. Antimicrob Agents Chemother. 1975 Nov;8(5):518–525. doi: 10.1128/aac.8.5.518. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrizosa J., Levison M. E., Kaye D. Double-blind controlled comparison of phlebitis produced by cephapirin and cephalothin. Antimicrob Agents Chemother. 1973 Feb;3(2):306–307. doi: 10.1128/aac.3.2.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lane A. Z., Chudzik G. M., Siskin S. B. Comparative pharmacokinetic studies of cephapirin and cephalothin following intravenous and intramuscular administration. Curr Ther Res Clin Exp. 1977 Jan;21(1):117–127. [PubMed] [Google Scholar]
- Lane A. Z., Taggart J. G., Iles R. L. Relative incidence of phlebitis caused by continuous intravenous infusion of cephapirin and cephalothin. Antimicrob Agents Chemother. 1972 Sep;2(3):234–235. doi: 10.1128/aac.2.3.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nightingale C. H., Greene D. S., Quintiliani R. Pharmacokinetics and clinical use of cephalosporin antibiotics. J Pharm Sci. 1975 Dec;64(12):1899–1926. doi: 10.1002/jps.2600641202. [DOI] [PubMed] [Google Scholar]
- Rozencweig M., Staquet M., Klastersky J. Antibacterial activity and pharmacokinetics of bacampicillin and ampicillin. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):592–597. doi: 10.1002/cpt1976195part1592. [DOI] [PubMed] [Google Scholar]
- Tan J. S., Salstrom S. J. Levels of carbenicillin, ticarcillin, cephalothin, cefazolin, cefamandole, gentamicin, tobramycin, and amikacin in human serum and interstitial fluid. Antimicrob Agents Chemother. 1977 Apr;11(4):698–700. doi: 10.1128/aac.11.4.698. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tan J. S., Trott A., Phair J. P., Watanakunakorn C. A method for measurement of antibiotics in human interstitial fluid. J Infect Dis. 1972 Nov;126(5):492–497. doi: 10.1093/infdis/126.5.492. [DOI] [PubMed] [Google Scholar]