Abstract
SCE-129 [3-4-carbamoyl-1-pyridiniomethyl-7β- (d-α-sulfophenylacetamido)-ceph-3-em-4-carboxylate] is a cephalosporin that inhibits Pseudomonas aeruginosa and Staphylococcus aureus. SCE-129 is tenfold more active than carbenicillin in inhibiting P. aeruginosa. SCE-129 has poor activity against Enterobacteriaceae compared with other cephalosporins and is 16-fold less active than the cephalosporins against streptococci. The activity of SCE-129 does not correlate with β-lactamase stability, although SCE-129 is resistant to hydrolysis by gram-positive and gram-negative bacteria. The compound does not inhibit the hydrolysis of other cephalosporins. Although SCE-129 acts synergistically with gentamicin to inhibit some Pseudomonas, this cannot be predicted based on knowledge of resistance to one or more compounds.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Heymès R., Lutz A., Schrinner E. Experimental evaluation of HR756, a new cephalosporin derivative: pre-clinical study. Infection. 1977;5(4):259–260. doi: 10.1007/BF01640793. [DOI] [PubMed] [Google Scholar]
- Neu H. C., Aswapokee N., Aswapokee P., Fu K. P. HR 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1979 Feb;15(2):273–281. doi: 10.1128/aac.15.2.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C., Winshell E. B. Purification and characterization of penicillinases from Salmonella typhimurium and Escherichia coli. Arch Biochem Biophys. 1970 Aug;139(2):278–290. doi: 10.1016/0003-9861(70)90479-0. [DOI] [PubMed] [Google Scholar]
- Tsuchiya K., Kondo M. Comparative in vitro activities of SCE-129, sulbenicillin, gentamicin, and dibekacin against Pseudomonas. Antimicrob Agents Chemother. 1978 Mar;13(3):536–539. doi: 10.1128/aac.13.3.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tsuchiya K., Kondo M., Nagatomo H. SCE-129, antipseudomonal cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1978 Feb;13(2):137–145. doi: 10.1128/aac.13.2.137. [DOI] [PMC free article] [PubMed] [Google Scholar]