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. 1979 May;15(5):658–661. doi: 10.1128/aac.15.5.658

Relationship Between Serum and Saliva Chloramphenicol Concentrations

Jeffrey R Koup †, Alan H Lau 1, Barbara Brodsky 2, Richard L Slaughter 1
PMCID: PMC352733  PMID: 525981

Abstract

The relationship between serum and saliva chloramphenicol (CAP) concentrations was evaluated in 27 paired specimens collected from 20 hospitalized patients during therapy with the drug. A significant (R = 0.80, P < 0.001) but variable relationship was found to exist. Serum protein binding of CAP was also evaluated (43.7 ± 5.7% bound; N = 24). Differences in CAP binding did not apparently account for a significant portion of the variability in the observed saliva/serum CAP concentration ratios. The degree of variation observed indicated that saliva CAP concentrations could not be relied upon for the prediction of serum CAP concentrations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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