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. 1979 Jun;15(6):758–762. doi: 10.1128/aac.15.6.758

Characteristics of Herpesvirus Mutants Resistant to Phosphonoformate and Phosphonoacetate

Bertil Eriksson 1, Bo Öberg 1
PMCID: PMC352754  PMID: 475360

Abstract

Mutants of herpes simplex virus type 1, resistant to phosphonoformate (PFA) and phosphonoacetate (PAA), have been selected in cell culture. The PFA-resistant mutant (HSV-PFAr) and the PAA-resistant mutant (HSV-PAAr) were also resistant to PAA and PFA, respectively. This cross-resistance indicates that PFA and PAA interact at the same site. The HSV-PFAr had a decreased susceptibility to vidarabine, but no difference in sensitivity to idoxuridine (5-iodo-2′-deoxyuridine) was observed when compared to the wild type. The induced deoxyribonucleic acid polymerases isolated from cells infected with HSV-PFAr and HSV-PAAr were both cross-resistant to inhibition by PFA and PAA. No increased resistance to vidarabine triphosphate could be observed, but the susceptibility to inhibition by pyrophosphate was about two times lower. None of the mutants showed any increased temperature sensitivity

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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