Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Jul;16(1):104–105. doi: 10.1128/aac.16.1.104

Isoniazid Inhibition of the Synthesis of Monounsaturated Long-Chain Fatty Acids in Mycobacterium tuberculosis H37Ra

Leslie A Davidson 1,2, Kuni Takayama 1,2
PMCID: PMC352798  PMID: 112917

Abstract

Isoniazid inhibited C24 and C26 monounsaturated fatty acid synthesis in Mycobacterium tuberculosis H37Ra. Time courses of this inhibition and that of mycolic acid synthesis were similar.

Full text

PDF
104

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Kanetsuna F. Chemical analyses of mycobacterial cell walls. Biochim Biophys Acta. 1968 Apr 16;158(1):130–143. doi: 10.1016/0304-4165(68)90080-9. [DOI] [PubMed] [Google Scholar]
  2. Lederer E., Adam A., Ciorbaru R., Petit J. F., Wietzerbin J. Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties. Mol Cell Biochem. 1975 May 30;7(2):87–104. doi: 10.1007/BF01792076. [DOI] [PubMed] [Google Scholar]
  3. Paulose M. M. The thin-layer chromatographic separation of fatty acid methyl esters according to both chain length and unsaturation. J Chromatogr. 1966 Jan;21(1):141–143. doi: 10.1016/s0021-9673(01)91277-4. [DOI] [PubMed] [Google Scholar]
  4. Qureshi N., Takayama K., Jordi H. C., Schnoes H. K. Characterization of the purified components of a new homologous series of alpha-mycolic acids from Mycobacterium tuberculosis H37Ra. J Biol Chem. 1978 Aug 10;253(15):5411–5417. [PubMed] [Google Scholar]
  5. Takayama K., Armstrong E. L., Davidson L. A., Kunugi K. A., Kilburn J. O. Effect of low temperature on growth, viability, and synthesis of mycolic acids of Mycobacterium tuberculosis strain H37Ra. Am Rev Respir Dis. 1978 Jul;118(1):113–117. doi: 10.1164/arrd.1978.118.1.113. [DOI] [PubMed] [Google Scholar]
  6. Takayama K., Qureshi N. Isolation and characterization of the monounsaturated long chain fatty acids of Mycobacterium tuberculosis. Lipids. 1978 Sep;13(9):575–579. doi: 10.1007/BF02535818. [DOI] [PubMed] [Google Scholar]
  7. Takayama K., Schnoes H. K., Armstrong E. L., Boyle R. W. Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis. J Lipid Res. 1975 Jul;16(4):308–317. [PubMed] [Google Scholar]
  8. Takayama K. Selective action of isoniazid on the synthesis of cell wall mycolates in mycobacteria. Ann N Y Acad Sci. 1974 May 10;235(0):426–438. doi: 10.1111/j.1749-6632.1974.tb43281.x. [DOI] [PubMed] [Google Scholar]
  9. Takayama K., Wang L., David H. L. Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1972 Jul;2(1):29–35. doi: 10.1128/aac.2.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Winder F. G., Collins P. B. Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis. J Gen Microbiol. 1970 Sep;63(1):41–48. doi: 10.1099/00221287-63-1-41. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES