Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Aug;16(2):123–126. doi: 10.1128/aac.16.2.123

Development of Resistance to Amphotericin B in Candida lusitaniae Infecting a Human

D Pappagianis 1, M S Collins 1, R Hector 1, J Remington 2
PMCID: PMC352808  PMID: 290351

Abstract

Candida lusitaniae associated with infection in a patient with acute myelogenous leukemia developed resistance to amphotericin B during systemic treatment of the patient. The organism, when isolated initially, was inhibited by 0.31 μg of amphotericin B per ml in yeast nitrogen base agar, but when isolated (20 days later) just antemortem and postmortem, required 100 and 50 μg/ml, respectively, for complete inhibition at 48 h.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRIOLE V. T., HASENCLEVER H. F. Factors influencing experimental candidiasis in mice. I. Alloxan diabetes. Yale J Biol Med. 1962 Aug;35:96–112. [PMC free article] [PubMed] [Google Scholar]
  2. Bodenhoff J. Resistance studies of Candida albicans, with special reference to two patients subjected to prolonged antimycotic treatment. Odontol Tidskr. 1968 Jun 28;76(3):279–294. [PubMed] [Google Scholar]
  3. Collins M. S. Inhibition of growth of Coccidioides immitis on Sabouraud medium containing polymyxin B. J Clin Microbiol. 1975 Mar;1(3):335–336. doi: 10.1128/jcm.1.3.335-336.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Drutz D. J., Lehrer R. I. Development of amphotericin B-resistant Candida tropicalis in a patient with defective leukocyte function. Am J Med Sci. 1978 Jul-Aug;276(1):77–92. [PubMed] [Google Scholar]
  5. Hamilton-Miller J. M. Fungal sterols and the mode of action of the polyene antibiotics. Adv Appl Microbiol. 1974;17(0):109–134. doi: 10.1016/s0065-2164(08)70556-2. [DOI] [PubMed] [Google Scholar]
  6. Holzschu D. L., Presley H. L., Miranda M., Phaff H. J. Identification of Candida lusitaniae as an opportunistic yeast in humans. J Clin Microbiol. 1979 Aug;10(2):202–205. doi: 10.1128/jcm.10.2.202-205.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rosen P. P. Opportunistic fungal infections in patients with neoplastic diseases. Pathol Annu. 1976;11:255–315. [PubMed] [Google Scholar]
  8. SORENSEN L. J., McNALL E. G., STERNBERG T. H. The development of strains of Candida albicans and Coccidioides immitis, which are resistant to amphotericin B. Antibiot Annu. 1958;6:920–923. [PubMed] [Google Scholar]
  9. Safe L. M., Safe S. H., Subden R. E., Morris D. C. Sterol content and polyene antibiotic resistance in isolates of Candida krusei, Candida parakrusei, and Candida tropicalis. Can J Microbiol. 1977 Apr;23(4):398–401. doi: 10.1139/m77-058. [DOI] [PubMed] [Google Scholar]
  10. Woods R. A., Bard M., Jackson I. E., Drutz D. J. Resistance to polyene antibiotics and correlated sterol changes in two isolates of Candida tropicalis from a patient with an amphotericin B-resistant funguria. J Infect Dis. 1974 Jan;129(1):53–58. doi: 10.1093/infdis/129.1.53. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES