Abstract
This paper describes an extension to an earlier account of the coliform flora carried by a married couple, one of whom was taking tetracycline for prolonged periods. The latter phase of this study was notable for the following: first, certain tetracycline-resistant Escherichia coli O antigen types persisted in one of the participants for several weeks after tetracycline was withdrawn; second, a course of ampicillin led to replacement of the tetracycline-resistant flora by one that was ampicillin resistant, but the end of the ampicillin course led to the reappearance of the tetracycline-resistant line, even though no tetracycline was being taken; and third, the tetracycline-sensitive O75 E. coli, which appeared toward the end of the survey, had not lost their plasmid but carried a derivative in which the tetracycline resistance gene(s) had been inactivated by the insertion of an extra piece of deoxyribonucleic acid with a molecular weight of about 1 megadalton.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bennett P. M., Richmond M. H. Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Eschericha coli. J Bacteriol. 1976 Apr;126(1):1–6. doi: 10.1128/jb.126.1.1-6.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grinsted J., Saunders J. R., Ingram L. C., Sykes R. B., Richmond M. H. Properties of a R factor which originated in Pseudomonas aeruginosa 1822. J Bacteriol. 1972 May;110(2):529–537. doi: 10.1128/jb.110.2.529-537.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartley C. L., Howe K., Linton A. H., Linton K. B., Richmond M. H. Distribution of R plasmids among the O-antigen types of Escherichia coli isolated from human and animal sources. Antimicrob Agents Chemother. 1975 Aug;8(2):122–131. doi: 10.1128/aac.8.2.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petrocheilou V., Grinsted J., Richmond M. H. R-plasmid transfer in vivo in the absence of antibiotic selection pressure. Antimicrob Agents Chemother. 1976 Oct;10(4):753–761. doi: 10.1128/aac.10.4.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Petrocheilou V., Richmond M. H., Bennett P. M. Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy. Antimicrob Agents Chemother. 1977 Aug;12(2):219–225. doi: 10.1128/aac.12.2.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wiedemann B., Knothe H. Untersuchungen über die Stabilität der Koliflora des gesunden Menschen. 1. Uber das Vorkommen permanenter und passanter Typen. Arch Hyg Bakteriol. 1969 Aug;153(4):342–348. [PubMed] [Google Scholar]