Abstract
The prevention of Candida endocarditis in the rabbit was easily accomplished with a single intramuscular injection of 75 mg of 5-FC (A predominantly fungistatic agent) per kg either 40 min before, or at the same time as, the intravenous challenge with Candida albicans. Renal infarcts were observed more often in rabbits with infected valvular vegetations than in control rabbits with sterile endocarditis. The prophylactic effect of 5-FC is greater in aortic vegetations than in the kidneys. This may be related to differences in the pathophysiology of infection and the pharmacokinetics of 5-FC in the two areas.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dismukes W. E., Karchmer A. W., Buckley M. J., Austen W. G., Swartz M. N. Prosthetic valve endocarditis. Analysis of 38 cases. Circulation. 1973 Aug;48(2):365–377. doi: 10.1161/01.cir.48.2.365. [DOI] [PubMed] [Google Scholar]
- Durack D. T., Petersdorf R. G. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J Clin Invest. 1973 Mar;52(3):592–598. doi: 10.1172/JCI107220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eilard T., Alestig K., Wahlén P. Treatment of disseminated candidiasis with 5-fluorocytosine. J Infect Dis. 1974 Aug;130(2):155–159. doi: 10.1093/infdis/130.2.155. [DOI] [PubMed] [Google Scholar]
- Freedman L. R., Johnson M. L. Experimental endocarditis. IV. Tricuspid and aortic valve infection with Candida albicans in rabbits. Yale J Biol Med. 1972 Apr;45(2):163–175. [PMC free article] [PubMed] [Google Scholar]
- Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
- Harford C. G. Postoperative fungal endocarditis. Fungemia, embolism, and therapy. Arch Intern Med. 1974 Jul;134(1):116–120. [PubMed] [Google Scholar]
- Slaughter L., Morris J. E., Starr A. Prosthetic valvular endocarditis. A 12-year review. Circulation. 1973 Jun;47(6):1319–1326. doi: 10.1161/01.cir.47.6.1319. [DOI] [PubMed] [Google Scholar]
- Southwick F. S., Durack D. T. Chemotherapy of experimental streptococcal endocarditis. 3. Failure of a bacteriostatic agent (tetracycline) in prophylaxis. J Clin Pathol. 1974 Apr;27(4):261–264. doi: 10.1136/jcp.27.4.261. [DOI] [PMC free article] [PubMed] [Google Scholar]