Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1979 Sep;16(3):266–270. doi: 10.1128/aac.16.3.266

Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.

R J Klein, E DeStefano, E Brady, A E Friedman-Kien
PMCID: PMC352843  PMID: 507784

Abstract

Topical treatment with 3% phosphonoformate of herpes simplex virus type 1 (HSV)-induced skin infections of hairless mice reduced the severity of skin lesions when the treatment was initiated 3 h after virus inoculation in the lumbosacral area or 3 and 24 h after inoculation in the orofacial area. The mortality was significantly reduced in lumbosacral-infected mice and was completely prevented in orofacial-infected mice when the treatment was initiated with a delay of 24 h after virus inoculation. However, phosphonoformate did not prevent the establishment of latent herpes simplex virus type 1 infections in the spinal and trigeminal ganglia, even when treatment was initiated as early as 3 h after infection.

Full text

PDF
266

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alenius S., Dinter Z., Oberg B. Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs. Antimicrob Agents Chemother. 1978 Sep;14(3):408–413. doi: 10.1128/aac.14.3.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Asher L. V., Walz M. A., Notkins A. L. Effect of immunization on the development of latent ganglionic infection in mice challenged intravaginally with herpes simplex virus types 1 and 2. Am J Obstet Gynecol. 1978 Aug 1;131(7):788–791. doi: 10.1016/0002-9378(78)90248-x. [DOI] [PubMed] [Google Scholar]
  3. Embil J. A., Stephens R. G., Manuel F. R. Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents. Can Med Assoc J. 1975 Oct 4;113(7):627–630. [PMC free article] [PubMed] [Google Scholar]
  4. Field H. J., Bell S. E., Elion G. B., Nash A. A., Wildy P. Effect of acycloguanosine treatment of acute and latent herpes simplex infections in mice. Antimicrob Agents Chemother. 1979 Apr;15(4):554–561. doi: 10.1128/aac.15.4.554. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Forghani B., Klassen T., Baringer J. R. Radioimmunoassay of herpes simplex virus antibody: correlation with ganglionic infection. J Gen Virol. 1977 Sep;36(3):371–375. doi: 10.1099/0022-1317-36-3-371. [DOI] [PubMed] [Google Scholar]
  6. Helgstrand E., Eriksson B., Johansson N. G., Lannerö B., Larsson A., Misiorny A., Norén J. O., Sjöberg B., Stenberg K., Stening G. Trisodium phosphonoformate, a new antiviral compound. Science. 1978 Sep 1;201(4358):819–821. doi: 10.1126/science.210500. [DOI] [PubMed] [Google Scholar]
  7. Kern E. R., Glasgow L. A., Overall J. C., Jr, Reno J. M., Boezi J. A. Treatment of experimental herpesvirus infections with phosphonoformate and some comparisons with phosphonoacetate. Antimicrob Agents Chemother. 1978 Dec;14(6):817–823. doi: 10.1128/aac.14.6.817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Klein R. J., Friedman-Kien A. E., DeStefano E. Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine. Antimicrob Agents Chemother. 1979 May;15(5):723–729. doi: 10.1128/aac.15.5.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Klein R. J., Friedman-Kien A. E., Fondak A. A., Buimovici-Klein E. Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice. Infect Immun. 1977 Jun;16(3):842–848. doi: 10.1128/iai.16.3.842-848.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Klein R. J., Friedman-Kien A. E. Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate. Antimicrob Agents Chemother. 1977 Nov;12(5):577–581. doi: 10.1128/aac.12.5.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Klein R. J., Friedman-Kien A. E., Yellin P. B. Orofacial herpes simplex virus infection in hairless mice: latent virus in trigeminal ganglia after topical antiviral treatment. Infect Immun. 1978 Apr;20(1):130–135. doi: 10.1128/iai.20.1.130-135.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reno J. M., Lee L. F., Boezi J. A. Inhibition of herpesvirus replication and herpesvirus-induced deoxyribonucleic acid polymerase by phosphonoformate. Antimicrob Agents Chemother. 1978 Feb;13(2):188–192. doi: 10.1128/aac.13.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stenberg K., Larsson A. Reversible effects on cellular metabolism and proliferation by trisodium phosphonoformate. Antimicrob Agents Chemother. 1978 Nov;14(5):727–730. doi: 10.1128/aac.14.5.727. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tenser R. B., Hsiung G. D. Pathogenesis of latent herpes simplex virus infection of the trigeminal ganglion in guinea pigs: effects of age, passive immunization, and hydrocortisone. Infect Immun. 1977 Apr;16(1):69–74. doi: 10.1128/iai.16.1.69-74.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wohlenberg C. R., Walz M. A., Notkins A. L. Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia. Infect Immun. 1976 May;13(5):1519–1521. doi: 10.1128/iai.13.5.1519-1521.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Young S. K., Rowe N. H., Buchanan R. A. A clinical study for the control of facial mucocutaneous herpes virus infections. I. Characterization of natural history in a professional school population. Oral Surg Oral Med Oral Pathol. 1976 Apr;41(4):498–507. doi: 10.1016/0030-4220(76)90277-2. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES