Abstract
To assess the efficacy of oral erythromycin in the treatment of nonspecific vaginitis (NSV), conducted a nonrandom, unblinded pilot study among 17 women with symptoms and signs of NSV. At the completion of treatment, 10 of 13 patients had persistent symptoms, 9 of 13 had persistent abnormal discharge, and 11 of 13 had persistently positive cultures for Haemophilus vaginalis. Ten patients with persistent or relapsing NSV and four who did not complete erythromycin treatment were retreated with oral metronidazole, and 14 of 14 showed clinical improvement and eradication of H. vaginalis. The susceptibility of 27 clinical isolates of H. vaginalis to erythromycin was determined at pH 5.5, 6.0, 6.5, and 7.0. The minimal inhibitory concentration of erythromycin for H. vaginalis was approximately 10-fold higher at pH 5.5 than at pH 7.0. Erythromycin is not effective for the treatment of H. vaginalis-associated NSV; this may be partly attributable to the reduced activity of this drug in acidic vaginal secretions.
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- Boggiano B. G., Gleeson M. Gastric acid inactivation of erythromycin stearate in solid dosage forms. J Pharm Sci. 1976 Apr;65(4):497–502. doi: 10.1002/jps.2600650406. [DOI] [PubMed] [Google Scholar]
- Chen K. C., Forsyth P. S., Buchanan T. M., Holmes K. K. Amine content of vaginal fluid from untreated and treated patients with nonspecific vaginitis. J Clin Invest. 1979 May;63(5):828–835. doi: 10.1172/JCI109382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dunkelberg W. E., Jr, Skaggs R., Kellogg D. S., Jr Method for isolation and identification of Corynebacterium vaginale (Haemophilus vaginalis). Appl Microbiol. 1970 Jan;19(1):47–52. doi: 10.1128/am.19.1.47-52.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GARDNER H. L., DUKES C. D. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol. 1955 May;69(5):962–976. [PubMed] [Google Scholar]
- Lee L., Schmale J. D. Ampicillin therapy for Corynebacterium vaginale (Haemophilus vaginalis) vaginitis. Am J Obstet Gynecol. 1973 Mar 15;115(6):786–788. doi: 10.1016/0002-9378(73)90521-8. [DOI] [PubMed] [Google Scholar]
- Lorian V., Sabath L. D. Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli. Appl Microbiol. 1970 Nov;20(5):754–756. doi: 10.1128/am.20.5.754-756.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pheifer T. A., Forsyth P. S., Durfee M. A., Pollock H. M., Holmes K. K. Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med. 1978 Jun 29;298(26):1429–1434. doi: 10.1056/NEJM197806292982601. [DOI] [PubMed] [Google Scholar]
- Rodgers H. A., Hesse F. E., Pulley H. C., Hines P. A., Smith R. F. Haemophilus vaginalis (Corynebacterium vaginale) vaginitis in women attending public health clinics: response to treatment with ampicillin. Sex Transm Dis. 1978 Jan-Mar;5(1):18–21. doi: 10.1097/00007435-197801000-00006. [DOI] [PubMed] [Google Scholar]
- Voogd C. E., Van der Stel J. J., Jacobs J. J. The mutagenic action of nitroimidazoles. I. Metronidazole, nimorazole, dimetridazole and ronidazole. Mutat Res. 1974 Dec;26(6):483–490. doi: 10.1016/s0027-5107(74)80049-7. [DOI] [PubMed] [Google Scholar]