Abstract
The pharmacokinetics of intravenous bolus doses of 1.0 g of mezlocillin were studied in 13 persons with normal and reduced renal functions. In renal failure a moderate increase was observed for the terminal serum half-life(t1/2 beta). This changed from a mean of 1.1 h at a glomerular filtration rate of 100 ml/min to 1.6 h at 10 ml/min. The difference was not statistically significant. The excretion of unchanged drug in urine during 24 h was reduced from a mean of 59.4% (range, 52 to 77) in subjects with glomerular filtration rate above 50 ml/min to 10% (range, 7.9 to 12.1) in two patients with glomerular filtration rate of 10 to 20 ml/min. The volume of distribution during the beta-phase, Vd,b, was 14% of the body weight. Much of the antibiotic was metabolized, and this proportion increased upon reduction in renal function.
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- Bergan T., Brodwall E. K., Oyri A. Renal excretion of gentamycin in chronic pyelonephritis. Acta Med Scand. 1971 Jan-Feb;189(1-2):1–5. doi: 10.1111/j.0954-6820.1971.tb04332.x. [DOI] [PubMed] [Google Scholar]
- Bergan T., Oydvin B. Microbiological assay of josamycin. Acta Pathol Microbiol Scand B Microbiol Immunol. 1972;80(1):101–106. doi: 10.1111/j.1699-0463.1972.tb00134.x. [DOI] [PubMed] [Google Scholar]
- Bergan T. Pharmacokinetics of mezlocillin in healthy volunteers. Antimicrob Agents Chemother. 1978 Dec;14(6):801–806. doi: 10.1128/aac.14.6.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fiegel P., Becker K. Pharmacokinetics of azlocillin in persons with normal and impaired renal functions. Antimicrob Agents Chemother. 1978 Sep;14(3):288–291. doi: 10.1128/aac.14.3.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Issell B. F., Bodey G. P., Weaver S. Clinical pharmacology of mezlocillin. Antimicrob Agents Chemother. 1978 Feb;13(2):180–183. doi: 10.1128/aac.13.2.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lode H., Niestrath U., Koeppe P., Langmaack H. Azlocillin und Mezlocillin: Zwei neue semisynthetische Acylureidopenicilline. Infection. 1977;5(3):163–169. doi: 10.1007/BF01639753. [DOI] [PubMed] [Google Scholar]
- Pancoast S. J., Neu H. C. Kinetics of mezlocillin and carbenicillin. Clin Pharmacol Ther. 1978 Jul;24(1):108–116. doi: 10.1002/cpt1978241108. [DOI] [PubMed] [Google Scholar]