Abstract
Recent clinical isolates of Bacteroides fragilis selected at random from four Detroit area hospitals were collected over a 3-month period, and the minimum inhibitory concentrations were determined within several days. The levels of antimicrobial agents used in this survey breached the concentration attainable in the patient's serum. The antimicrobial susceptibility patterns of these isolates to five antimicrobial agents suggest that there is a 20% variation in the resistance to clindamycin and also up to 20% variation among the other four antibiotics in the four area hospitals. The changing susceptibility pattern of B. fragilis to antibiotic resistance suggests that minimum inhibitory concentrations should be determined for all isolates from serious clinical infections.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Blazevic D. J. Antibiotic susceptibility of the subspecies of Bacteroides fragilis. Antimicrob Agents Chemother. 1976 Mar;9(3):481–484. doi: 10.1128/aac.9.3.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guiney D. G., Jr, Davis C. E. Identification of a conjugative R plasmid in Bacteroides ochraceus capable of transfer to Escherichia coli. Nature. 1978 Jul 13;274(5667):181–182. doi: 10.1038/274181a0. [DOI] [PubMed] [Google Scholar]
- Salaki J. S., Black R., Tally F. P., Kislak J. W. Bacteroides fragilis resistant to the administration of clindamycin. Am J Med. 1976 Mar;60(3):426–428. doi: 10.1016/0002-9343(76)90759-2. [DOI] [PubMed] [Google Scholar]
- Saunders J. R. Anaerobes and transferable drug resistance. Nature. 1978 Jul 13;274(5667):113–114. doi: 10.1038/274113a0. [DOI] [PubMed] [Google Scholar]
- Sutter V. L., Finegold S. M. Susceptibility of anaerobic bacteria to 23 antimicrobial agents. Antimicrob Agents Chemother. 1976 Oct;10(4):736–752. doi: 10.1128/aac.10.4.736. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wikins T. D., Holdeman L. V., Abramson I. J., Moore W. E. Standardized single-disc method for antibiotic susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1972 Jun;1(6):451–459. doi: 10.1128/aac.1.6.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkins T. D., Chalgren S. Medium for use in antibiotic susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1976 Dec;10(6):926–928. doi: 10.1128/aac.10.6.926. [DOI] [PMC free article] [PubMed] [Google Scholar]