Table 2.

Active licensed treatment arms of interest

Combination therapy	Abatacept 10 mg/kg/4 weeks + MTX
	Adalimumab 40 mg/2 weeks + MTX
	Certolizumab pegol 200 mg/2 weeks + MTX
	Etanercept 2 × 25 mg/week + MTX
	Golimumab 50 mg/4 weeks + MTX
	Infliximab 3 mg/kg/8 weeks + MTX
	Rituximab 2 × 1000 mg + MTX
	Tocilizumab 8 mg/kg/4 weeks + MTX
	Controls – DMARD monotherapy (= MTX or sulfasalazine)
Monotherapy	Adalimumab 40 mg/2 weeks
	Certolizumab pegol 200 mg/2 weeks
	Etanercept 2 × 25 mg/week
	Tocilizumab 8 mg/kg/4 weeks
	Control (= placebo or sulfasalazine)

Abbreviations: DMARD, disease-modifying antirheumatic drug; MTX, methotrexate.